摘要
三叉神经痛表现为三叉神经感觉分布区的剧烈疼痛,可由刷牙、洗脸等无伤害性刺激触发而反复发作,病程时间长,患者深受慢性疼痛的折磨。目前三叉神经痛的治疗主要包括口服药物及手术治疗。文中报道了1例92岁高龄的三叉神经痛患者,因不能耐受药物不良反应及手术治疗,疼痛得不到缓解。为了兼顾起效时间及疗效维持时间,在联合A型肉毒毒素及中华眼镜蛇短链α-神经毒素治疗后,患者的疼痛症状很快缓解并维持了8个月。文中总结了该患者的临床特点、探讨了两种联用药物的作用机制,旨在为临床提供更多的方案选择。
Trigeminal neuralgia is characterized by intense pain in the sensory distribution area of the trigeminal nerve.It can be triggered by non-noxious stimuli such as brushing teeth and washing face.At present,the treatment of trigeminal neuralgia mainly includes oral drugs and surgical treatments.A 92-year-old patient with trigeminal neuralgia was reported.The pain could not be alleviated because the patient was unable to tolerate the side effects of drugs and surgical treatment.Taking into account the onset time and the duration of the curative effect,botulinum toxin type A was combined with cobrotoxin for the treatment of the patient.As a result,the pain symptoms were rapidly alleviated and remained in a relieved state for 8 months.The clinical characteristics of this patient were summarized in this article,and the possible synergistic mechanisms of action of the 2 drugs were discussed.The ultimate objective is to furnish a broader spectrum of alternatives and references for clinical practice.
作者
徐莹莹
马舒扬
黎英
鲍吉利
徐周
郭成伟
刘晶
罗蔚锋
Xu Yingying;Ma Shuyang;Li Ying;Bao Jili;Xu Zhou;Guo Chengwei;Liu Jing;Luo Weifeng(Department of Neurology,the Second Affiliated Hospital of Soochow University,Suzhou 215004,China;Department of Neurology,Zhangjiagang First People′s Hospital,Zhangjiagang 215600,China)
出处
《中华神经科杂志》
北大核心
2025年第4期426-429,共4页
Chinese Journal of Neurology
作者简介
通信作者:罗蔚锋,Email:lwfwxx@126.com。
