摘要
目的:评价修和方加减联合紫杉醇(PTX)+铂类方案对手术切除气血两虚型卵巢癌(OC)患者近远期预后、中医证候和免疫功能的影响。方法:选取接受手术切除治疗的气血两虚型OC患者80例,根据术后治疗方案不同分为化疗组(PTX+铂类方案)和联合组(修和方加减联合PTX+铂类方案),各40例。观察并比较两组患者的近远期预后、中医证候改善情况以及免疫功能变化。结果:联合组客观有效率明显高于化疗组(77.50%与52.50%,P<0.05),中位PFS和中位OS亦显著长于化疗组(P<0.05);两组治疗后中医证候总积分均较治疗前明显减少(P<0.05),而联合组减少幅度更大(P<0.05);联合组治疗后CD4^(+)、CD4^(+)/CD8^(+)、NK细胞活性明显高于化疗组,CD8^(+)显著低于化疗组(P<0.05);联合组与化疗组在不良反应的分级中比较有统计学差异(P<0.05)。结论:修和方加减联合PTX+铂类方案能够显著提高手术切除OC(气血两虚证)患者的近远期疗效,改善中医证候,增强患者的免疫功能,用药具有一定安全性。
Objective:To evaluate the effects of modified Xiuhe Prescription combined with paclitaxel(PTX)and platinum on the short-term and long-term prognosis,traditional Chinese medicine syndromes,and immune function of patients with surgically resected ovarian cancer(OC)of qi and blood deficiency type.Methods:80 patients with qi and blood deficiency type OC who underwent surgical resection were selected and divided into a chemotherapy group(PTX+platinum)and a combination group(modified Xiuhe prescription combined with PTX+platinum)according to different postoperative treatment plans,with 40 patients in each group.Observe and compare the short-term and long-term prognosis,improvement of traditional Chinese medicine syndromes,and changes in immune function between two groups of patients.Results:The objective effective rate of the combination group was higher than that of the chemotherapy group(77.50%vs.52.50%,P<0.05),and the median PFS and median OS were also longer than those of the chemotherapy group(P<0.05).After treatment,the total score of traditional Chinese medicine syndrome in both groups decreased compared to before treatment(P<0.05),with a greater decrease in the combination group(P<0.05).After treatment,the CD4^(+),CD4^(+)/CD8^(+),and NK cell activity in the combination group were significantly higher than those in the chemotherapy group,while CD8^(+)was significantly lower than that in the chemotherapy group(P<0.05).The combination group and the chemotherapy group compared in the grade of myelosuppression,gastrointestinal reaction,neurological and hepatorenal toxicity(P<0.05).Conclusion:The combination of modified Xiuhe Prescription and PTX+platinum can significantly improve the short-and long-term efficacy of surgical resection of OC(Qi and Blood Deficiency Syndrome)patients,improve traditional Chinese medicine syndromes,enhance patients’immune function,and has certain safety.
作者
殷蓓丽
蔡奚梅
钱云英
须慕棠
YIN Beili;CAI Ximei;QIAN Yunying;XU Mutang(Department of Obstetrics and Gynecology,Changshu Traditional Chinese Medicine Hospital,Changshu 215500,China)
出处
《陕西中医》
2025年第5期634-637,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
江苏省妇幼健康科研项目(F202014)。
关键词
卵巢癌
气血两虚证
修和方加减
PTX
铂类
预后
中医证候
免疫功能
Ovarian cancer
Qi and blood deficiency syndrome
Modified Xiuhe Prescription
PTX
Platinum
Prognosis
Traditional Chinese Medicine Syndrome
Immunity
作者简介
第一作者:殷蓓丽,硕士,住院医师,从事中医妇科学研究,E-mail:y1250625040@163.com;通信作者:须慕棠,本科,主治医师,从事妇产科常见病、多发病研究,E-mail:zzhouzhee@163.com。
