摘要
过渡金属元素Fe、Cu和Zn是生命活动的关键元素,其同位素有望作为示踪人体疾病的新指标。文章介绍了Fe、Cu、Zn同位素在医学中应用的一些基本原理和近年来在医学诊断和代谢方面的应用,其中Fe同位素能有效示踪与Fe代谢相关的疾病;Cu同位素在示踪肝病和癌症方面有着重要作用;Zn同位素可作为分泌器官癌症的有效示踪剂。依据现有这三种同位素在医学方面的应用,对未来的前景提出了展望,希望能进一步推动金属稳定同位素在医学方面的研究和应用,建立医学诊断中金属稳定同位素的指标。
The transition metals Fe,Cu and Zn are the key elements for life,and their isotope compositions are expected to be a new index to diagnose human diseases.This article reviewed the principle of Fe,Cu and Zn isotopes in medicine,and the research of their application in medical diagnosis.Because Fe isotopes can effectively trace the diseases related to Fe metabolism,Cu isotopes plays an important role in tracing liver disease and cancer,and Zn isotopes can be used as an effective tracer for cancer in secretory organs,these isotopes can be used in medical diagnosis.We hope this study will promote the research and application of metal stable isotopes in medicine and establish the index of metal stable isotope in medical diagnosis.
作者
郭瑞
于慧敏
张华凤
荚卫东
黄方
GUO Rui;YU Huimin;ZHANG Huafeng;JIA Weidong;HUANG Fang(CAS Key Laboratory of Crust-Mantle Materials and Environments,School of Earth and Space Sciences,University of Science and Technology of China,Hefei 230026,China;CAS Center for Excellence in Comparative Planetology,University of Science and Technology of China,Hefei 230026,China;Key Laboratory of Immune Response and Immunotherapy,Division of Life Science and Medicine,University of Science and Technology of China,Hefei 230022,China;Department of General Surgery,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230036,China)
出处
《高校地质学报》
北大核心
2025年第2期185-199,共15页
Geological Journal of China Universities
基金
国家自然科学基金(42330101)资助。
作者简介
郭瑞,女,1999年生,硕士研究生,主要从事金属同位素医学研究,E-mail:guorui420@mail.ustc.edu.cn;通讯作者:于慧敏,女,1979年生,副研究员,主要从事非传统稳定同位素分析方法及地质应用研究,E-mail:huy16@ustc.edu.cn。
