摘要
目的 探讨重复经颅磁刺激(rTMS)联合电针与耳穴压豆治疗抑郁患者的效果及对神经递质水平的影响。方法 选取2021年9月至2022年9月郑州市第八人民医院精神科诊治的100例抑郁患者,随机分为两组,每组50例。对照组接受常规药物治疗,观察组在对照组基础上加用rTMS联合电针与耳穴压豆治疗。比较两组治疗前后Hamilton抑郁量表(HAMD)评分、5-羟色胺(5-HT)水平、多巴胺(DA)水平、去甲肾上腺素(NE)水平、临床疗效及不良反应情况。结果 治疗后,观察组HAMD评分及血清5-HT、DA、NE水平均优于对照组(P<0.05)。观察组的治愈率、显著改善率、改善率和总有效率均高于对照组(P<0.05)。两组患者在治疗过程中均未出现严重的不良反应,仅有少数患者出现轻微的头痛、头晕、恶心等症状,不良反应发生率差异无统计学意义(P>0.05)。结论 rTMS联合电针与耳穴压豆治疗抑郁患者,可有效改善患者症状和神经递质水平,提高疗效。
Objective To explore the clinical efficacy of repetitive transcranial magnetic stimulation(rTMS)combined with electroacupuncture and auricular acupressure on depression patients and its effect on neurotransmitter levels.Methods A total of 100 depression patients who visited Department of Psychiatric in the Eighth People’s Hospital of Zhengzhou from September 2021 to September 2022 were selected and randomly divided into two groups,50 cases in each group.The control group received conventional drug therapy,while the observation group received rTMS combined with electroacupuncture and auricular acupressure on the basis of the control group.The Hamilton depression scale(HAMD)scores,serum 5-hydroxytryptamine(5-HT),dopamine(DA),norepinephrine(NE)levels,clinical efficacy and adverse reactions of the two groups before and after treatment were compared.Results After treatment,the HAMD scores,serum 5-HT,DA,NE levels of the observation group were better than those of the control group(P<0.05).The cure rate,significant improvement rate,improvement rate and total effective rate of the observation group were higher than those of the control group(P<0.05).No serious adverse reactions occurred in both groups during the treatment process,only a few patients had mild symptoms such as headache,dizziness,nausea,etc.,and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion rTMS combined with electroacupuncture and auricular acupressure can significantly improve the clinical symptoms and neurotransmitter levels of depression patients,and improve the therapeutic effect.
作者
徐东
鲍天昊
王珊
XU Dong;BAO Tianhao;WANG Shan(Department of Psychiatry,the Eighth People’s Hospital of Zhengzhou,Zhengzhou 450006,China;Department of Geriatric Medicine,Mental Health Center Affiliated to Kunming Medical University,Kunming 650500,China;Department of Psychology,Mental Health Center Affiliated to Zhengzhou University,Zhengzhou 450006,China)
出处
《河南医学研究》
2025年第8期1438-1441,共4页
Henan Medical Research
关键词
抑郁
重复经颅磁刺激
电针
耳穴压豆
神经递质
depression
repetitive transcranial magnetic stimulation
electroacupuncture
auricular acupressure
neurotransmitter
