摘要
Background:Platelet endothelial cell adhesion molecule(PECAM-1)is present in the vascular endothelium and plays important roles in various biological processes.Several recent studies have reported associations between PECAM-1 and certain subtypes of cardiovascular diseases(CVDs).However,further research is necessary to clarify the causal effects of PECAM-1 on CVDs.To determine whether PECAM-1 and CVDs are causally associated,we conducted a two-sample Mendelian randomization(TSMR)study.Methods:Single nucleotide polymorphisms(SNPs)associated with PECAM-1 were used as instrumental variants(IVs)to estimate the causal effects of PECAM-1 on CVDs.Six SNPs were included in our TSMR study.The inverse-variance weighted(IVW)method was applied in the primary analysis.To confirm the initial results,we conducted several complementary analyses and pleiotropy analyses.Results:In the IVW analysis,higher genetically predicted PECAM-1 levels were associated with lower risk of coronary artery disease(CAD)(OR,0.835;CI,0.757–0.92;P=3×10-4)and myocardial infarction(MI)(OR,0.79;CI,0.709–0.881;P=2.03×10-5).Conclusions:The findings confirmed that elevated PECAM-1 levels may decrease the risk of CAD and MI.These results confirm the causal effect of PECAM-1 on CVDs and may facilitate further investigation of the mechanism of PECAM-1 in CVD pathogenesis.
基金
supported by grants from the Ministry of Science and Technology of China(2021YFA0804803 and 2022YFA1104204)
National Natural Science Foundation of China(82421001,82230014,81930007,81470389,81500221,81930012,and 82241027)
the National Science Fund for Distinguished Young Scholars(81625002)
Shanghai Municipal Health Commission(2022JC013,2023ZZ02021,and GWVI-11.1-26)
Shanghai Municipal Education Commission(SHSMU-ZDCX20210700)
Shanghai Hospital Development Center(SHDC12022102)
the Science and Technology Commission of Shanghai Municipality(22JC1402100 and 22DZ2292400)
the Major Project of Natural Science Foundation of Hunan Province(Open Competition 2021JC0002).
作者简介
Mingze Sun,contribute equally to this study;Yiming Zhong,contribute equally to this study;Correspondence:Alex F.Chen,Institute for Developmental and Regenerative Cardiovascular Medicine,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China,E-mail:chenfengyuan@xinhuamed.com.cn;Correspondence:Jun Pu,Department of Cardiology,State Key Laboratory of Systems Medicine for Cancer,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China,E-mail:pujun310@hotmail.com。
