摘要
目的:分析降钙素原(PCT)和血清淀粉样蛋白A(SAA)水平与布鲁氏菌病患者病情及治疗效果的关系。方法:选取70例布鲁氏菌病患者为研究对象,根据病情严重程度将患者分为轻度组(n=34)和重度组(n=36)。所有患者接受标准抗布鲁氏菌病治疗,收集并比较所有患者治疗前后PCT和SAA水平;多因素Logistic回归分析影响患者病情及治疗效果的危险因素;采用Spearman相关性分析PCT、SAA水平与病情及治疗效果的关系;通过受试者工作特征(ROC)曲线评估血清PCT和SAA水平对布鲁氏菌病患者病情的预测能力。结果:治疗前,重度组的PCT和SAA水平高于轻度组(P<0.05)。治疗后,两组PCT、SAA水平均降低(P<0.05),但无统计学差异(P>0.05)。多因素Logistic回归分析显示,血清PCT和SAA水平是影响布鲁氏菌病严重程度的独立危险因素(P<0.05)。Spearman相关性分析显示,血清PCT和SAA水平与布鲁氏菌病严重程度正相关(P<0.05),与治疗效果负相关(P<0.05)。ROC曲线分析显示,血清PCT和SAA水平诊断布鲁氏菌病情严重程度的曲线下面积(AUC)分别为0.781、0.866(P<0.05)。二者联合诊断的AUC为0.934,敏感度为0.806,特异度为0.882(P<0.05)。结论:PCT和SAA水平与布鲁氏菌病患者的病情严重程度及治疗效果密切相关,可作为评估病情和治疗效果的重要指标。
Objective:To analyze the relationship between procalcitonin(PCT) and serum amyloid A(SAA) levels and disease condition and therapeutic effect of patients with brucellosis.Methods:70 patients with brucellosis were enrolled in this study and were divided into mild group(n=34) and severe group(n=36) by means of the disease severity.All patients received standard anti-brucellosis treatment.The clinical data of patients with brucellosis were collected,and the levels of PCT and SAA were compared among all patients and between mild group and severe group before and after treatment.Multivariate Logistic regression analysis was used to analyze the risk factors affecting the disease condition and therapeutic effect of patients.Spearman correlation analysis was applied to analyze the relationship of PCT and SAA levels with disease condition and therapeutic effect.Receiver operating characteristic(ROC) curve was adopted to evaluate the predictive ability of serum PCT and SAA levels on disease condition in patients with brucellosis.Results:Before treatment,the PCT and SAA levels in severe group were higher than those in mild group(P<0.05).After treatment,the levels of PCT and SAA decreased in both groups(P<0.05),but there was no statistically significant difference between the two groups(P>0.05).Multivariate Logistic regression analysis indicated that serum PCT and SAA levels were independent risk factors for severity of brucellosis(P<0.05).Spearman correlation analysis suggested that serum PCT and SAA were positively correlated with brucellosis severity(P<0.05),and were negatively correlated with therapeutic effect(P<0.05).ROC curve analysis showed that the AUCs of serum PCT and SAA levels in the diagnosis of disease severity of brucellosis were 0.781 and 0.866 respectively(P<0.05).The AUC,sensitivity and specificity of combined diagnosis were 0.934,0.806 and 0.882(P<0.05).Conclusion:The levels of PCT and SAA are closely related to the disease severity and therapeutic effect of patients with brucellosis,and can be used as important indicators to evaluate the disease condition and therapeutic effect.
作者
史潇君
黄宇
袁子清
张磊
SHI Xiao-jun;HUANG Yu;YUAN Zi-qing;ZHANG Lei(Department of Infectious Diseases,Fuyang Second People s Hospital,Fuyang 236015,Anhui,China)
出处
《川北医学院学报》
2025年第3期353-357,共5页
Journal of North Sichuan Medical College
基金
安徽省阜阳市重点研究与开发计划项目(FYZDYF2023LCYX035)。
作者简介
史潇君(1991-),男,主治医师。E-mail:632462993@qq.com。
