摘要
目的分析急性缺血性脑卒中(AIS)患者采用丁苯酞软胶囊与双联抗血小板药物联合治疗的效果。方法60例AIS患者,参照随机数字表分为对照组和研究组,每组30例。对照组采用双联抗血小板药物治疗,研究组在对照组基础上联用丁苯酞软胶囊治疗。对比两组临床疗效、神经损伤标志物水平、不良反应发生情况。结果研究组治疗总有效率96.67%高于对照组的73.33%(P<0.05)。治疗4周后,研究组基质金属蛋白酶9(MMP-9)(46.30±5.22)ng/ml、神经元特异性烯醇化酶(NSE)(14.60±1.09)ng/ml低于对照组的(63.20±6.08)、(17.50±1.10)ng/ml(P<0.05)。两组不良反应发生率对比无差异(P>0.05)。结论AIS患者采用丁苯酞软胶囊与双联抗血小板药物联合治疗效果确切,能够改善神经损伤标志物,安全性较为理想。
Objective To analyze the effect of butylphthalide soft capsules combined with dual antiplatelet drugs in the treatment of acute ischemic stroke(AIS).Methods A total of 60 patients with AIS were divided into control group and study group according to the random number table,with 30 patients in each group.The control group was treated with dual antiplatelet drugs,and the study group was treated with butylphthalide soft capsules on the basis of the control group.The clinical efficacy,the level of markers of nerve injury and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of 96.67%in the study group was higher than 73.33%in the control group(P<0.05).After 4 weeks of treatment,matrix metalloproteinase-9(MMP-9)and neuron-specific enolase(NSE)were(46.30±5.22)ng/ml and(14.60±1.09)ng/ml in the study group,which were lower than(63.20±6.08)and(17.50±1.10)ng/ml in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of butylphthalide soft capsules and dual antiplatelet drugs has a definite effect on AIS patients,which can improve the markers of nerve injury and has ideal safety.
作者
周庆海
ZHOU Qing-hai(Department of Neurology,Wucheng County People's Hospital of Shandong Province,Dezhou 253300,China)
出处
《中国实用医药》
2025年第4期80-82,共3页
China Practical Medicine
