摘要
2型糖尿病(type 2 diabetes mellitus,T2DM)是一种常见的代谢性和内分泌疾病,长期高血糖水平会导致多种严重的慢性并发症,给社会和患者带来巨大的经济负担。尽管目前有多种降糖药物可供临床使用,但它们往往无法满足T2DM并发症的治疗需求。因此,迫切需要寻找新的治疗策略和药物。木姜叶柯被誉为集茶、糖、药于一体的“树上虫草”,在传统医学中具有悠久的使用历史。研究发现,木姜叶柯提取物富含二氢查尔酮类化合物,主要包括三叶苷、根皮苷和根皮素,具有抗炎、抗氧化、降血糖、降血脂、肝脏保护及心脏保护等多种药理活性,这使得它们在治疗T2DM及其并发症方面具有潜在的应用价值。该综述系统收集并整理了近十年关于木姜叶柯提取物中二氢查尔酮类化合物(三叶苷、根皮苷和根皮素)的相关文献,重点阐述了它们通过降低胰岛素抵抗、调节葡萄糖转运、改善糖脂代谢、调控酶类活性、调节肠道菌群,以及抗炎和抗氧化损伤等机制治疗T2DM及其并发症方面的最新研究进展。旨在为木姜叶柯提取物中的二氢查尔酮(三叶苷、根皮苷和根皮素)防治T2DM及其并发症的进一步研究提供参考和依据。
Type 2 diabetes mellitus(T2DM)is a prevalent metabolic and endocrine disorder.Long-term hyperglycemia can lead to severe chronic complications,imposing substantial economic burdens on both society and patients.Despite the availability of various hypoglycemic agents for clinical use,these agents often fail to meet the therapeutic needs of T2DM and its complications.Consequently,there is an urgent need for novel therapeutic strategies and drugs.Lithocarpus litseifolius(L.litseifolius),commonly referred to as"cordyceps on trees",has a long history of use in traditional medicine and can be applied in tea,sugar,and medicine.Research indicates that L.litseifolius extracts are rich in dihydrochalcones,including trilobatin,phloridzin,and phloretin,which exhibit a range of pharmacological activities,such as anti-inflammatory,antioxidant,hypoglycemic,hypolipidemic,hepatoprotective,and cardioprotective effects.These properties suggest potential applications in the treatment of T2DM and its complications.This review systematically compiled and organized the relevant literature from the past decade on dihydrochalcones(trilobatin,phloridzin,and phloretin)from L.litseifolius extracts.It highlighted recent research progress regarding their role in treating T2DM and its complications through mechanisms such as reducing insulin resistance,regulating glucose transport,improving glucose and lipid metabolism,modulating enzyme activity,regulating gut microbiota,and alleviating inflammation and oxidative damage.The purpose of this review is to provide a reference and basis for future research on the prevention and treatment of T2DM and its complications using dihydrochalcones(trilobatin,phloridzin,and phloretin)from L.litseifolius extracts.
作者
韦运钦
蔡玉兰
阳琰
樊尚珩
吴林丽
聂桂兰
WEI Yun-qin;CAI Yu-lan;YANG Yan;FAN Shang-heng;WU Lin-li;NIE Gui-lan(the Second Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
出处
《中国中药杂志》
北大核心
2025年第3期658-671,共14页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(82060159,82260167)
贵州省科技计划项目(黔科合支撑[2020]Y010号,黔科合基础-ZK[2022]一般639)
贵州省中医药管理局中医药、民族医药科学技术研究课题(QZYY-2023-043)
遵义市科技计划项目(遵市科合HZ字[2022]279号)
遵义医科大学附属医院博士科研启动资金项目(院字[2021]6号)
遵义市联合基金项目(遵市科合HZ字[2022]332号)。
关键词
木姜叶柯
二氢查尔酮
三叶苷
根皮苷
根皮素
2型糖尿病
并发症
Lithocarpus litseifolius
dihydrochalcones
trilobatin
phloridzin
phloretin
type 2 diabetes mellitus
complications
作者简介
韦运钦,硕士研究生,主要从事中医药防治内分泌疾病的研究,E-mail:1294000633qq.com;通信作者:阳琰,教授,博士生导师,主要从事维生素D、中医药防治内分泌疾病的相关研究,E-mail:2006yangyan80@163.com。
