摘要
目的:观察乙酰半胱氨酸联合机械辅助排痰治疗肺炎支原体肺炎患儿的效果。方法:回顾性分析2022年1月至2024年1月该院收治的200例肺炎支原体肺炎患儿的临床资料,按治疗方案不同将其分为观察组与对照组各100例。对照组给予机械辅助排痰治疗,观察组在对照组基础上联合吸入用乙酰半胱氨酸溶液治疗,比较两组临床症状消失时间,治疗前后肺功能指标[第1秒用力呼气容积(FEV_(1))、呼气流量峰值(PEF)、FEV_(1)/用力肺活量(FVC)]、免疫球蛋白指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]、炎性因子[C反应蛋白(CRP)、降钙素原(PCT)]水平,以及不良反应发生率。结果:观察组肺部啰音、发热、持续性干咳等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);两组FEV_(1)、PEF、FEV_(1)/FVC水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组IgA、IgG、IgM水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组CRP、PCT水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:乙酰半胱氨酸联合机械辅助排痰治疗肺炎支原体肺炎患儿可缩短临床症状消失时间,提高肺功能指标和免疫球蛋白指标水平,以及降低炎性因子水平的效果优于单纯机械辅助排痰治疗。
Objective:To observe effects of Acetylcysteine combined with mechanical assisted expectoration in treatment of children with mycoplasma pneumoniae pneumonia.Methods:The clinical data of 200 children with mycoplasma pneumoniae pneumonia admitted to this hospital from January 2022 to January 2024 were retrospectively analyzed.According to different treatment plans,they were divided into observation group and control group,100 cases in each group.The control group was treated with mechanical assisted expectoration,while the observation group was treated with Acetylcysteine solution for inhalation on the basis of that of the control group.The disappearance time of clinical symptoms,the levels of pulmonary function indexes[forced expiratory volume in one second (FEV_(1)),peak expiratory flow (PEF),FEV_(1)/forced vital capacity (FVC)],immunoglobulin indexes[immunoglobulin A (IgA),immunoglobulin G (IgG),immunoglobulin M (IgM)]and inflammatory factors[C-reactive protein (CRP),procalcitonin (PCT)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The disappearance time of clinical symptoms such as lung rales,fever and persistent dry cough in the observation group was shorter than that in the control group,and the difference was statistically significant (P<0.05).The levels of FEV_(1),PEF and FEV_(1)/FVC in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05).The levels of IgA,IgG and IgM in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant (P<0.05).The levels of CRP and PCT in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusions:Acetylcysteine combined with mechanical assisted expectoration in the treatment of the children with mycoplasma pneumoniae pneumonia can shorten the disappearance time of clinical symptoms,improve the levels of pulmonary function indexes and immunoglobulin indexes,and reduce the levels of inflammatory factors.Moreover,it is superior to simple mechanical assisted expectoration treatment.
作者
赵永阳
ZHAO Yongyang(Xunwu County People’s Hospital,Ganzhou 342299 Jiangxi,China)
出处
《中国民康医学》
2025年第5期41-43,53,共4页
Medical Journal of Chinese People’s Health
关键词
肺炎支原体肺炎
乙酰半胱氨酸
机械辅助排痰
肺功能
免疫球蛋白
炎性因子
不良反应
Mycoplasma pneumoniae pneumonia
Acetylcysteine
Mechanical assisted expectoration
Lung function
Immunoglobulin
Inflammatory factor
Adverse reaction
作者简介
赵永阳(1989.03-),男,汉族,江西赣州人,本科,主治医师,研究方向为儿科疾病的诊治。
