摘要
目的观察阿托伐他汀+阿司匹林治疗高血压伴发动脉粥样硬化的效果,评估其对患者生活质量的影响。方法选取遂川县人民医院2020年1月-2023年10月收治的高血压伴发动脉粥样硬化患者70例为研究对象,按照随机数字表法分为对照组35例和观察组35例。对照组选择阿司匹林治疗,观察组在其基础上予以阿托伐他汀治疗。比较两组临床疗效、生活质量水平、血压水平、血脂指标[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、三酰甘油(TG)]、颈动脉内膜中层厚度(CIMT)以及不良反应发生率。结果观察组治疗总有效率为94.29%,与对照组的85.71%比较,差异有统计学意义(P<0.05);与治疗前相比,两组生活质量评分均提高,且与对照组比较,观察组生活质量评分更高(P<0.05);与治疗前相比,两组收缩压、舒张压均降低,且与对照组比较,且观察组收缩压、舒张压更低(P<0.05);与治疗前相比,两组LDL-C、TC、TG均降低,HDL-C升高,且与对照组比较,观察组LDL-C、TC、TG水平更低,HDL-C更高(P<0.05);两组治疗后CIMT均小于治疗前,且与对照组比较,观察CIMT更小(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论阿托伐他汀+阿司匹林治疗高血压伴发动脉粥样硬化的临床效果确切,可提高患者生活质量水平,改善血脂指标,降低血压水平,减小颈动脉内膜中层厚度,同时不增加不良反应,具有良好的应用有效性和安全性。
Objective To observe the effect of atorvastatin+aspirin in the treatment of hypertension with atherosclerosis,and to evaluate its effect on the quality of life.Methods Using the random number table method,totally 70 patients with hypertension and atherosclerosis admitted to Suichuan County People's Hospital from January 2020 to October 2023 were divided into control group(n=35)and observation group(n=35).The control group was treated with aspirin,and the observation group was treated with atorvastatin on the basis of the control group.The control group was treated with aspirin,and the observation group was treated with atorvastatin on the basis of the control group.The clinical efficacy,quality of life level,blood pressure level,blood lipid indexes[low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),total cholesterol(TC),triglyceride(TG)],carotid intima-media thickness(CIMT)and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.29%,which was compared with 85.71%in the control group,the difference was statistically significant(P<0.05).Compared with before treatment,the quality of life scores of the two groups were improved,and the quality of life score of the observation group was higher than that of the control group(P<0.05).Compared with before treatment,the systolic blood pressure and diastolic blood pressure of the two groups decreased,and compared with the control group,the systolic blood pressure and diastolic blood pressure of the observation group were lower(P<0.05).Compared with before treatment,the levels of LDL-C,TC and TG in the two groups decreased,and HDL-C increased.Compared with the control group,the levels of LDL-C,TC and TG in the observation group were lower,and HDL-C was higher(P<0.05).The CIMT of the two groups after treatment was less than that before treatment,and compared with the control group,the CIMT was smaller(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Atorvastatin combined with aspirin is effective in the treatment of patients with hypertension and atherosclerosis,which can improve their quality of life,improve blood lipid indexes,reduce blood pressure levels,and reduce carotid intima-media thickness without increasing adverse reactions.It has good application effectiveness and safety.
作者
曾清平
ZENG Qingping(Department of Pharmacy,Suichuan County People′s Hospital,Suichuan 343900,Jiangxi,China)
出处
《医学信息》
2025年第3期130-133,共4页
Journal of Medical Information
作者简介
曾清平(1979.6-),男,江西吉安人,本科,主管药师,主要从事临床药学工作。
