摘要
冠状动脉粥样硬化性心脏病(简称“冠心病”)是导致心绞痛、心肌梗死、心力衰竭、猝死等病症的主要原因之一,人参活性成分可通过多靶点、多途径发挥防治冠心病的作用。人参活性成分通过调控沉默信息调节器1/核因子κB信号通路、下调环磷酸腺苷/蛋白激酶A信号通路,来减轻炎症反应、降低心肌缺血引起的炎性损伤。人参活性成分通过增强核因子E2相关因子2/血红素加氧酶-1信号通路,激活腺苷酸活化的蛋白激酶/沉默信息调节因子2相关酶/p53信号通路,减轻氧化应激反应,降低心肌缺血引起的氧化损伤。人参活性成分通过抑制血管平滑肌细胞表型转化、抑制过氧化物酶体增殖物活化受体-γ/粘着斑激酶信号通路,来延缓动脉粥样硬化进程、降低心肌缺血引起的损伤。人参活性成分通过促进核因子E2相关因子2/血红素加氧酶-1信号通路表达,激活再灌注损伤补救激酶/内皮型一氧化氮合成酶/一氧化氮信号通路、磷脂酰肌醇3-激酶/蛋白激酶B/雷帕霉素靶蛋白信号通路、沉默信息调节器1信号通路,调节凋亡相关蛋白的表达,降低心肌细胞凋亡,对心肌细胞发挥保护作用。人参活性成分通过抑制腺苷酸环化酶—环磷酸腺苷—蛋白激酶A信号通,调节内皮素—一氧化氮的动态平衡,调节心肌舒缩功能,减轻心肌损伤。人参活性成分通过抑制钙离子内流,下调钙/钙调蛋白依赖性蛋白激酶II蛋白的表达,抑制过氧化物酶体增殖物活化受体-γ的表达,减轻心律失常,降低心肌损伤。人参活性成分通过下调Ras同源基因家族成员A信号通路,增强线粒体自噬,保护线粒体功能,改善心肌能量代谢,减轻心肌损伤。人参活性成分通过减轻内质网应激反应,降低心肌损伤。
Coronary heart disease was one of the main causes of diseases such as angina pectoris,myocardial infarction,heart failure,and sudden death.The active ingredients of ginseng played a role in preventing and treating coronary heart disease through multiple targets and pathways.Ginseng active ingredients can regulate SIRT1/NF-κB signaling pathway,down-regulate cAMP/PKA signaling pathway,reduce inflammatory response,and reduce inflammatory damage caused by myocardial ischemia.Ginseng active ingredients can enhance Nrf2/HO-1 signaling pathway,activate AMPK/SIRT3/p53 signaling pathway,reduce oxidative stress response,and reduce oxidative damage caused by myocardial ischemia.Ginseng active ingredients can inhibit phenotypic transformation of vascular smooth muscle cells and inhibit PPAR-γ/FAK signaling pathway,delay the progression of atherosclerosis,and reduce damage caused by myocardial ischemia.Ginseng active ingredients can promote the expression of Nrf2/HO-1 signaling pathway,activate RISK/eNOS/NO signaling pathway,activate PI3K/Akt/mTOR signaling pathway,activate SIRT1 signaling pathway,regulate the expression of apoptosis-related proteins,reduce cardiomyocyte apoptosis,and play a protective role on cardiomyocytes.Ginseng active ingredients can regulate the dynamic balance of ET-NO,regulate myocardial systolic and diastolic function,and reduce myocardial damage by inhibiting adenylate cyclase(AC)-cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway.Ginseng active ingredients can inhibit calcium influx,down-regulate the expression of CaMKII protein,inhibit the expression of PPAR-γ,reduce arrhythmias,and reduce myocardial damage.Ginseng active ingredients can down-regulate the RhoA signaling pathway,enhance mitochondrial autophagy,protect mitochondrial function,improve myocardial energy metabolism,and reduce myocardial damage.Ginseng active ingredients can reduce myocardial damage by reducing endoplasmic reticulum stress response.
作者
郭啸
谭绍坤
宋红莉
GUO Xiao;TAN Shaokun;SONG Hongli(Graduate School,Hebei University of Traditional Chinese Medicine,Shijiazhuang 050091,China)
出处
《环球中医药》
2025年第2期372-380,共9页
Global Traditional Chinese Medicine
基金
河北省中医药管理局(2024160)。
关键词
人参
活性成分
冠状动脉粥样硬化性心脏病
药理作用
炎症反应
氧化应激反应
动脉粥样硬化
细胞凋亡
舒缩功能
线粒体自噬
心律失常
能量代谢
ginseng
active ingredients
coronary heart disease
pharmacological action
inflammatory response
oxidative stress response
atherosclerosis
apoptosis
systolic and diastolic function
mitochondrial autophagy
arrhythmias
energy metabolism
作者简介
郭啸(1996-),2021级在读硕士研究生。研究方向:心血管病。E-mail:17631639369@163.com;通信作者:宋红莉(1971-),硕士,主任中医师。研究方向:心血管病。E-mail:songhlxt@163.com。
