摘要
目的基于预培其损理论探究泰山磐石散加减联合地屈孕酮及黄体酮对不明原因复发性流产(脾肾两虚证)患者妊娠情况的影响。方法纳入自2022年9月—2023年8月于医院妇产科就诊的不明原因复发性流产脾肾两虚证患者83例,以随机数字表法随机分为两组。对照组42例,排卵后予地屈孕酮,妊娠后加服黄体酮胶囊治疗;观察组41例,先予泰山磐石散加减服用至少3个月经周期,妊娠后予泰山磐石散及地屈孕酮和黄体酮口服治疗,两组均治疗至妊娠12周。比较两组患者持续妊娠率(至孕12周)、孕三项激素水平、中医证候积分、临床疗效。结果治疗后观察组中医证候积分、持续妊娠率(至孕12周)、临床疗效均优于对照组,差异有统计学意义(P<0.05)。两组患者孕酮、雌二醇、人绒毛膜促性腺激素均随孕周增加逐渐升高,观察组孕酮在各时期差异无统计学意义(P>0.05),雌二醇在孕4~5、6、8周均高于对照组,差异有统计学意义(P<0.05),人绒毛膜促性腺激素在孕4~5周时两组差异无统计学意义(P>0.05),在孕6、8周时,观察组高于对照组,差异有统计学意义(P<0.05)。结论泰山磐石散加减联合地屈孕酮及黄体酮胶囊治疗不明原因复发性流产效果良好,优于单纯西药治疗,值得推广应用。
Objective To explore the clinical effect of Taishan Panshi Powder(泰山磐石散)combined with dydrogesterone and progesterone on the pregnancy of patients with unexplained recurrent spontaneous abortion(URSA)with spleen-kidney deficiency syndrome based on the theory of the preventive treatment of insufficiency.Methods A total of 83 patients with USRA(spleen-kidney deficiency syndrome)who were admitted to the obstetrics and gynecology department of our hospital from September 2022 to August 2023 were assigned into control groups and observation group randomly in which 42 patients in the control group while 41 in another.The control group was given dydrogesterone after ovulation and progesterone capsule after pregnancy;the observation group was given Taishan Panshi Powder for at least three menstrual cycles and dydrogesterone and progesterone after pregnancy.Both groups were treated until 12 weeks of gestation.The rate of continuous pregnancy(to 12 weeks of gestation),the levels of three hormones in pregnancy,TCM syndrome score and clinical efficacy were compared between the two groups.Results After treatment,the TCM syndrome score,continuous pregnancy rate(to 12 weeks)and clinical efficacy of the observation group were better than those of the control group,with statistical significance(P<0.05).P,E2 and HCG in the two groups gradually increased with the increase of gestational weeks,and P levels in each stage had no significant difference(P>0.05);E2 levels in the observation group were higher than those in the control group at 4-5,6 and 8 weeks of gestation,with statistical significance(P<0.05);HCG levels in the two groups at 4-5 weeks of gestation had no statistical significance(P>0.05).The observation group was pregnant at 6 and 8 weeks,it was higher than the control group,the difference was statistically significant(P<0.05).Conclusion Taishan Panshi Powder combined with dydrogesterone and progesterone capsule had a good effect in the treatment of unexplained recurrent abortion,which was superior to Western medicine alone,and worthy of promotion and application.
作者
赵小茜
孙晶
陈莹
ZHAO Xiaoqian;SUN Jing;CHEN Ying(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《中西医结合慢性病杂志》
2025年第1期63-68,共6页
JOURNAL OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE ON CHRONIC DISEASES
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函〔2022〕75号)
辽宁省科技计划联合计划(应用基础研究项目)(2023JH2/101700230)
辽宁省辽派中医学术经验和技能活态传承项目(辽卫中综合字〔2021〕19号)。
关键词
不明原因复发性流产
泰山磐石散
脾肾两虚
临床观察
unexplained recurrent abortion
Taishan Panshi Powder(泰山磐石散)
spleen-kidney deficiency
clinical observation
作者简介
赵小茜(1998-),女(满族),辽宁丹东人,硕士在读,研究方向:中西医治疗妇产科疾病;通讯作者:孙晶(1979-),女,辽宁大连人,主任医师,硕士研究生导师,博士,研究方向:中西医治疗妇产科疾病。E-mail:sunjing790825@126.com。
