摘要
目的:评估改良富血小板纤维蛋白(advanced platelet-rich fibrin,A-PRF)、浓缩生长因子(concentrated growth factor,CGF)结合纳米羟基磷灰石在上颌窦外提升种植术中的临床应用效果。方法:选择2023年4月—2024年3月泰康仙林鼓楼医院行上颌窦外提升种植术的患者68例。采用随机数字表法分为对照组(n=34,Bio-Oss大颗粒植骨材料)和联合组(n=34,A-PRF、CGF联合纳米羟基磷灰石)。对比2组患者的术后症状、骨水平、伤口愈合状况、种植体稳定系数(implant stability quotient,ISQ)、黏膜愈合状况及并发症发生情况。采用SPSS 27.0软件包对数据进行统计学分析。结果:联合组患者术后1个月及3个月自觉症状评分显著低于对照组(P<0.05),术后6个月骨密度、骨增量、骨高度显著低于对照组,ISQ值、角化龈宽度及厚度显著高于对照组(P<0.05)。联合组患者一期愈合率高于对照组,愈合时间低于对照组(P<0.05)。联合组不良事件发生率与对照组相比无统计学差异(P>0.05)。结论:A-PRF与CGF联合纳米羟基磷灰石在上颌窦外提升种植术中能显著改善植骨质量,提高种植体稳定性,加速术后康复。
PURPOSE:To evaluate the clinical efficacy of advanced platelet-rich fibrin(A-PRF)and concentrated growth factor(CGF)combined with nano-hydroxyapatite in external maxillary sinus lift implantation.METHODS:A total of 68 patients who underwent external maxillary sinus lift implantation from April 2023 to March 2024 at Taikang Xianlin Gulou Hospital were selected.They were randomly assigned to the control group(n=34,using Bio-Oss large particle bone graft material)and combined group(n=34,using A-PRF and CGF combined with nano-hydroxyapatite).Postoperative symptoms,bone levels,wound healing status,stability coefficient,mucosal healing,and complications were compared between the two groups.SPSS 27.0 software package was used for statistical analysis of the data.RESULTS:At 1 month and 3 months after operation,the conscious symptom score in combination group was significantly lower than that in the control group(P<0.05),bone mineral density,bone increment and bone height at 6 months after operation were significantly lower than those in the control group;ISQ value,keratinized gingiva width and thickness were significantly higher than those in the control group(P<0.05).The primary healing rate I in combination group was higher than that in the control group,and the healing time was lower than that in the control group(P<0.05).There was no significant difference in the occurrence of adverse events between the combined and control groups(P>0.05).CONCLUSIONS:The combination of A-PRF and CGF with nano-hydroxyapatite significantly improves bone quality,enhances implant stability,and accelerates postoperative recovery in external maxillary sinus lift implantation.
作者
刘秉尧
虞晓东
李翠梅
尚卫华
LIU Bing-yao;YU Xiao-dong;LI Cui-mei;SHANG Wei-hua(Department of Stomatology,Taikang Xianlin Gulou Hospital,Nanjing 210046,Jiangsu Province,China)
出处
《上海口腔医学》
2025年第1期43-47,共5页
Shanghai Journal of Stomatology
基金
江苏省科技项目合同(BK20190250)。
作者简介
刘秉尧(1982-),男,博士,副主任医师;通信作者:刘秉尧,E-mail:m13115031516@163.com。
