摘要
随着耐药细菌的快速增长,有机抑菌剂已无法满足社会公共卫生需求,高活性复合抑菌剂不仅可以保留单组分的性质,还可以显示出更加优异的抑菌性能,因而成为抑菌材料的重要研究方向。本研究通过制备纳米Cu_(2)S材料,然后与3-(苯并噻唑-2-巯基)丙烷磺酸钠(SBPF)反应,制备出结构新颖的Cu_(2)S@SBPF材料,采用TEM、XRD、UV-vis、FTIR及XPS等测试手段对样品的微观形貌、结构、元素组成等进行表征,探究了该复合材料对革兰氏阴性菌大肠杆菌(E.coli)、革兰氏阳性菌金黄色葡萄球菌(S.aureus)和耐药菌沙门氏菌(T-Salmonella)的抑菌性能。结果表明,浓度为500μg/mL的复合材料在60 min时对E.coli、S.aureus和T-Salmonella的抑菌率均达到99.99%且对E.coli最为敏感。抑菌机制表明,该复合材料能破坏细菌的细胞壁进入细菌内部,抑制细菌呼吸,最终使细菌死亡。这一成果有望为解决细菌耐药问题提供新的方案。
With the rapid growth of drug-resistant bacteria,organic bacteriostatic agents have been unable to meet the needs of social public health.High-activity composite bacteriostatic agents can not only retain the properties of single components,but also show more excellent antibacterial properties,thus becoming an important research direction of antibacterial materials.In this study,a novel structure Cu_2S@sodium 3-(benzothiazol-2-ylthio)-1-propanesulfonate(SBPF)material,TEM,XRD,UV-vis,FTIR and XPS were used to characterize the micromorphology,structure and elemental composition of the samples.The antibacterial properties of the composite against Gramnegative bacteria E.coli,Gram-positive bacteria S.aureus and drug-resistant bacteria T-Salmonella were investigated.The results showed that the antibacterial rate of the composite at the concentration of 500μg/mL to E.coli,S.aureus and T-Salmonella reached 99.99%at 60 min,and the composite was the most sensitive to E.coli.The antibacterial mechanism showed that the composite material could destroy the cell wall of bacteria into the interior of bacteria,inhibit bacterial respiration,and eventually cause bacterial death.This result is expected to provide a new solution to solve the problem of bacterial drug resistance.
作者
汪艳
张强
陈惠惠
邱莹
胡瑞玲
李亚鹏
赵欣鑫
安雪
刘荟芝
郭少波
WANG Yan;ZHANG Qiang;CHEN Huihui;QIU Ying;HU Ruiling;LI Yapeng;ZHAO Xinxin;AN Xue;LIU Huizhi;GUO Shaobo(School of Chemistry and Environmental Science,Shaanxi University of Technology,Hanzhong 723000,China;School of Biological Science and Engineering,Shaanxi University of Technology,Hanzhong 723000,China)
出处
《复合材料学报》
北大核心
2025年第1期491-503,共13页
Acta Materiae Compositae Sinica
基金
陕西省教育厅项目(20JS015)
陕西省自然科学基金(2023-YBGY-486)
陕西理工大学基础研究基金(SLGRCQD2309)。
关键词
Cu_(2)S
苯并噻唑
复合材料
协同抑菌
医药
Cu_(2)S
benzothiazole
composite materials
synergistic inhibition of bacteria
medicine
作者简介
通信作者:张强,博士,教授,硕士生导师,研究方向为多环芳烃的合成,E-mail:zhangqiang22@126.com。
