摘要
目的探讨甲酰肽受体(FPR)2、6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3(PFKFB3)水平与急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后远期预后的关系。方法选取2020年1月至2022年12月于该院接受PCI术的AMI患者171例(AMI组)和同时间段体检健康者60例(对照组)作为研究对象。AMI患者根据PCI术后1年是否发生主要不良心血管事件(MACE)分为预后不良组和预后良好组。采用酶联免疫吸附试验检测血清FPR2、PFKFB3水平。通过多因素Logistic回归分析AMI患者PCI术后远期预后的影响因素。采用受试者工作特征(ROC)曲线分析血清FPR2、PFKFB3对AMI患者PCI术后远期不良预后的预测价值。结果与对照组比较,AMI组血清FPR2、PFKFB3水平升高(P<0.05)。随访1年,171例AMI患者PCI术后MACE发生率为25.73%(44/171)。与预后良好组比较,预后不良组血清FPR2、PFKFB3水平升高(P<0.05)。AMI患者PCI术后远期不良预后的危险因素为年龄增加、KILLIP分级≥Ⅱ级、FPR2水平升高、PFKFB3水平升高(P<0.05)。血清FPR2联合PFKFB3预测AMI患者PCI术后远期不良预后的曲线下面积为0.868,大于FPR2、PFKFB3单独预测的0.795、0.797(P<0.05)。结论血清FPR2、PFKFB3水平升高为AMI患者PCI术后远期不良预后的危险因素,血清FPR2联合PFKFB3对远期不良预后的预测价值较高。
Objective To investigate the relationship between formyl peptide receptor(FPR)2,6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3(PFKFB3)levels and long-term prognosis after percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI).Methods A total of 171 patients with acute myocardial infarction(AMI)who underwent PCI at this hospital from January 2020 to December 2022(AMI group)and 60 healthy individuals who underwent physical examinations during the same period(control group)were selected as research subjects.The AMI patients were divided into the poor prognosis group and the good prognosis group based on whether they experienced major adverse cardiovascular events(MACE)within one year after PCI.Serum levels of FPR2 and PFKFB3 were measured by enzyme-linked immunosorbent assay(ELISA).Multivariate Logistic regression analysis was performed to identify the factors influencing long-term adverse prognosis after PCI in AMI patients.The predictive value of serum FPR2 and PFKFB3 for long-term adverse prognosis after PCI in AMI patients was analyzed by receiver operating characteristic(ROC)curve.Results Compared with the control group,the serum levels of FPR2 and PFKFB3 were elevated in the AMI group(P<0.05).After one year of follow-up,the incidence of MACE after PCI in 171 AMI patients was 25.73%(44/171).Compared with the good prognosis group,serum levels of FPR2 and PFKFB3 were higher than those in the poor prognosis group(P<0.05).The risk factors for long-term adverse prognosis after PCI in AMI patients were increased age,KILLIP class≥Ⅱ,elevated FPR2 level and elevated PFKFB3 level(P<0.05).The area under the curve(AUC)for serum FPR2 combined with PFKFB3 in predicting long-term adverse prognosis after PCI in AMI patients was 0.868,which was superior to the AUC for FPR2(0.795)and PFKFB3(0.797)alone(P<0.05).Conclusion Elevated serum levels of FPR2 and PFKFB3 are risk factors for long-term adverse prognosis after PCI in AMI patients,and the combined detection of serum FPR2 and PFKFB3 provides a higher predictive value for this prognosis.
作者
史苏娜
贾相科
白敬淼
杨柳
侯维娜
刘欢欢
SHI Suna;JIA Xiangke;BAI Jingmiao;YANG Liu;HOU Weina;LIU Huanhuan(Department of Cardiology,Xingtai Central Hospital,Xingtai,Hebei 054000,China;Ultrasound Room,Xingtai Central Hospital,Xingtai,Hebei 054000,China)
出处
《检验医学与临床》
2025年第4期536-540,546,共6页
Laboratory Medicine and Clinic
基金
河北省医学科学研究课题计划项目(20220312)
河北省邢台市重点研发计划项目(2024ZC191)。
作者简介
史苏娜,女,主治医师,主要从事冠心病及介入治疗方向的研究。
