摘要
复方肾华片是一种用于治疗慢性肾病、肾病综合征、糖尿病肾病、急性肾衰竭及免疫球蛋白A(IgA)肾病的有效复方制剂,其可通过抗炎、调节免疫功能、保护肾脏细胞改善肾脏功能,具有良好的开发前景。但目前肾华片的药效物质基础及作用机制尚不清晰,这制约了其临床应用和推广。从肾华片的方证分析、保护肾脏作用机制及组方中药的有效成分对肾脏保护作用的研究3个方面进行综述,为肾华片药效物质基础和作用机制研究提供参考。
Shenhua Tablets are effective compound preparations for the treatment of chronic nephropathy,nephrotic syndrome,diabetic nephropathy,acute renal failure,and IgA nephropathy.It can improve renal function by suppressing inflammation,regulating immune function,and protecting renal cells,having a good development prospect.However,the efficacy material base and mechanism of action of Shenhua Tablets are unclear,which restricts their clinical application and promotion.This paper reviewed research on the protection effect of Shenhua Tablets on kidneys through prescription and syndrome analysis,mechanism of action,and effective components of prescriptions,so as to provide reference for the research on the efficacy material base and mechanism of action of Shenhua Tablets.
作者
王宇航
尹凤婷
刘慧强
闫广利
孙晖
王喜军
WANG Yuhang;YIN Fengting;LIU Huiqiang;YAN Guangli;SUN Hui;WANG Xijun(Heilongjiang University of Chinese Medicine,State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine,National Chinmedomics Research Center,Harbin 150040,China)
出处
《中国现代中药》
2025年第2期381-392,共12页
Modern Chinese Medicine
基金
国家自然科学基金项目(32141005)。
关键词
肾华片
肾病
药理作用
作用机制
药效物质基础
Shenhua Tablet
nephropathy
pharmacological effects
mechanism of action
efficacy material base
作者简介
通信作者:王喜军,教授,研究方向:中药血清药物化学及中医方证代谢组学,E-mail:xijunw@sina.com;孙晖,教授,研究方向:中药体内成分分析及中药质量标准研究,E-mail:Suihui7045@163.com。
