摘要
目的:建立基于加权逼近理想解排序(TOPSIS)法的急性淋巴细胞白血病(ALL)患儿大剂量甲氨蝶呤(HDMTX)药物利用评价(DUE)标准,促进临床合理用药。方法:以甲氨蝶呤(MTX)药品说明书为依据,参考HDMTX临床使用相关指南和文献,建立基于加权TOPSIS法的ALL患儿HDMTX的DUE标准。依据DUE标准回顾性评价我院2021-2023年HDMTX使用情况。结果:150份病历加权TOPSIS法评价显示,相对接近程度(Ci)≤60%的有15例(10.00%),60%~70%的有51例(34.00%),>70%~80%的有73例(48.67%),≥80%的有11例(7.33%)。结论:本研究建立的DUE标准可用于HDMTX在儿童的应用合理性评价;评价结果显示我院HDMTX临床应用存在不合理情况,需进一步加强管控和多学科协作,促进合理用药。
Objective:To establish the drug utilization evaluation(DUE)and typical case analysis of high-dose methotrexate(HDMTX)in children with acute lymphoblastic leukemia(ALL)based on weighted technique for order preference by similarity to ideal solution(TOPSIS)method,so as to promote the clinical rational application.Methods:Based on drug instructions of methotrexate(MTX)and by referring to relevant clinical guidelines and literature on the clinical application of HDMTX,DUE criterion for HDMTX in ALL children based on the weighted TOPSIS method was established.The application of HDMTX in our hospital from 2021 to 2023 was retrospectively evaluated according to the DUE criteria.Results:According to the weighted TOPSIS method evaluation of 150 medical records,the weighted Euclid distance(Ci)was≤60% in 15 cases(10%),from 60% to 70% in 51 cases(34.00%),>70% to 80%in 73 cases(48.67%),and≥80% in 11 cases(7.33%).Conclusion:The evaluation criteria of HDMTX in children with ALL based on weighted TOPSIS method can be used to evaluate the application rationality in children.The evaluation results show that there are irrational clinical application of HDMTX in our hospital,and it is necessary to further strengthen the control and multidisciplinary cooperation,and promote the rational medication.
作者
孙丽
许锦
赵兴辉
吴庆涛
韩兆欢
安琪
刘育青
王磊
Sun Li;Xu Jin;Zhao Xinghui;Wu Qingtao;Han Zhaohuan;An Qi;Liu Yuqing;Wang Lei(Xuzhou Children’s Hospital,Xuzhou Medical University,Jiangsu Xuzhou 221006,China)
出处
《儿科药学杂志》
2025年第2期1-5,共5页
Journal of Pediatric Pharmacy
基金
徐州市卫生健康委员会药学科研项目,编号XWYXKY202303
江苏省药学会-奥赛康医院药学科研项目,编号A202339
徐州医科大学附属徐州市儿童医院科研项目,编号23040419。
关键词
急性淋巴细胞白血病
儿童
加权逼近理想解排序法
大剂量甲氨蝶呤
药物利用评价
acute lymphocyte leukemia
children
weighted technique for order preference by similarity to ideal solution method
highdose methotrexate
drug utilization evaluation
作者简介
孙丽(1985.03-),女,大学本科,副主任药师,主要从事循证药学、治疗药物监测与个体化给药研究,E-mail:sunligw@163.com;通信作者:吴庆涛(1982.12-),男,大学本科,副主任药师,主要从事循证药学、治疗药物监测与个体化给药研究,E-mail:1656987140@qq.com。
