摘要
川崎病(KD)是一种急性系统性血管炎,可导致冠状动脉病变(CAL)的发生,是目前儿童获得性心脏病的首要原因。近年来,血小板在KD及其心血管病变中的作用越来越受重视,其活化与血栓形成和免疫炎症反应密切相关。本综述回顾了最新文献,主要从血小板的角度探讨KD及CAL的发病机制。
Kawasaki disease(KD)is an acute systemic vasculitis that can lead to coronary artery lesions(CAL),and become the leading cause of acquired heart disease in children.In recent years,increasing attention has been paid to the role of platelets in the development of KD and its cardiovascular complications.Platelet activation is closely associated with thrombus formation and immune-inflammatory responses.In this review,the latest literature is examined to investigate the role of platelets in the occurrence of KD and CAL.
作者
蒙嘉慧
刘芳
Meng Jiahui;Liu Fang(Heart Center,Children′s Hospital of Fudan University,Shanghai 201102,China)
出处
《中华实用儿科临床杂志》
北大核心
2025年第1期68-70,共3页
Chinese Journal of Applied Clinical Pediatrics
基金
国家自然科学基金(82070513,82100524)。
关键词
血小板
川崎病
冠状动脉病变
冠状动脉瘤
Platelet
Kawasaki disease
Coronary artery lesion
Coronary artery aneurysm
作者简介
通信作者:刘芳,Email:liufang@fudan.edu.cn。
