摘要
目的应用早孕期超声参数评估体外受精-胚胎移植(IVF-ET)技术对早孕期胚胎发育的影响。资料与方法回顾性选取2020—2022年北京市海淀区妇幼保健院建档早孕期超声提示单活胎且随访至13^(+6)周时无不良妊娠结局的864例孕妇,根据其受孕方式分为IVF-ET组256例和自然受孕(SC)组608例,按孕龄分为6、7、8周亚组,对IVF-ET组早孕期超声指标进行纵向研究,并与SC组进行比较。对孕妇年龄进行分层,比较两种受孕方式下,不同年龄组超声指标的差异。采用单因素线性回归分析头臀长(CRL)和妊娠囊平均直径(mGSD)的相关性。结果两组孕妇CRL、mGSD均随孕周增加而增大(F=83.592~840.037,P<0.05),而mGSD-CRL随孕周增加无明显变化(P>0.05);SC组与IVF-ET组相比早孕期各孕周CRL、mGSD、mGSD-CRL差异无统计学意义(t=0.282~1.713,P>0.05)。当对孕妇年龄进行分层比较时,两组孕妇高龄和非高龄间超声参数差异均无统计学意义(P>0.05),IVF-ET高龄组和SC高龄组间、IVF-ET非高龄组和SC非高龄组间超声参数差异均无统计学意义(P>0.05);单因素线性回归分析显示,IVF-ET组及SC组早孕期CRL和mGSD呈正相关(t=3.586、9.665、11.170、7.690、11.307、12.263,P<0.05)。结论早孕期妊娠囊和胚胎呈规律性同步增长,IVF-ET技术及年龄不会影响其生长规律。
Purpose To assess the impact of in vitro fertilization-embryo transfer(IVF-ET)technology on early embryonic development by using early pregnancy ultrasound parameters.Materials and Methods A retrospective study was conducted on 864 pregnant women who had their early pregnancy ultrasounds at the Haidian District Maternal and Child Health Hospital in Beijing from 2020 to 2022.These women had singleton viable pregnancies with no adverse pregnancy outcomes followed up to 13^(+6) weeks.They were divided into two groups,based on their method of conception,including IVF-ET group and spontaneously conceived(SC)group.Subgroups were further divided according to the gestational age indicated by ultrasound at 6,7 and 8 weeks.A longitudinal study of early pregnancy ultrasound indicators was conducted in the IVF-ET group and compared with the corresponding parameters in the SC group.The ages of the pregnant women were stratified to compare the differences in ultrasound indicators between the two conception methods at different ages.Univariate linear regression analysis was used to assess the correlation between crown-rump length(CRL)and mean gestational sac diameter(mGSD).Results The CRL and mGSD of pregnant women in both groups increased with gestational age(P<0.05),while the mGSD-CRL did not show significant changes with the increase in gestational age(F=83.592-840.037,P>0.05).There were no statistically significant differences in CRL,mGSD and mGSD-CRL at each gestational week during early pregnancy between the SC group and the IVF-ET group(t=0.282-1.713,P>0.05).When comparing the ultrasound parameters stratified by maternal age,there were no statistically significant differences in ultrasound parameters between the elderly and non-elderly subgroups within both groups(P>0.05).There were also no statistically significant differences in ultrasound parameters between the elderly subgroup of the IVF-ET group and the SC group,as well as between the non-elderly subgroup of the IVF-ET group and the SC group(P>0.05).Univariate linear regression analysis showed a positive correlation between CRL and mGSD in the early pregnancy period for both the IVF-ET group and the SC group(t=3.586,9.665,11.170,7.690,11.307,12.263,P<0.05).Conclusion During early pregnancy,the gestational sac and embryo exhibit regular synchronous growth,and IVF-ET technology and age do not affect their growth patterns.
作者
梁甜甜
吴青青
李晓菲
王晶晶
LIANG Tiantian;WU Qingqing;LI Xiaofei;WANG Jingjing(Department of Ultrasound,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Care Hospital,Beijing 100026,China)
出处
《中国医学影像学杂志》
北大核心
2025年第1期68-72,90,共6页
Chinese Journal of Medical Imaging
关键词
体外受精
胚胎移植
妊娠初期
超声检查
年龄
孕龄
In vitro fertilization-embryo transfer
Early pregnancy
Ultrasound
Age
Pregnant women
作者简介
通信作者:吴青青.qingqingwu@ccmu.edu.cn。
