摘要
精神药物治疗在精神疾病领域中至关重要,由于个体差异导致的药物疗效和安全性问题不容忽视。遗传因素,特别是与药物代谢酶、药物作用靶点和风险相关的基因多态性,对药物反应具有显著影响。药物基因组学通过检测基因多态性,能够获知患者对药物的药效、药代动力学特性和潜在毒性的遗传倾向,进而预测药物治疗效果和不良反应,为个体化治疗提供指导。因此,基于药物基因组学的个体化用药有助于提高治愈率、降低复发率,同时减少医疗成本,对精神疾病临床用药具有重大意义。
Psychotropic medication plays a crucial role in the field of mental illness,and the issues of drug efficacy and safety due to individual differences cannot be ignored.Genetic factors,especially the genetic polymorphisms related to drug-metabolizing enzymes,drug action targets,and risk,have a significant impact on drug responses.Pharmacogenomics,by detecting genetic polymorphisms,can reveal a patient′s inherited tendencies towards drug efficacy,pharmacokinetic characteristics,and potential toxicity,thereby predicting the therapeutic effects and adverse reactions of drug treatment,and providing guidance for personalized therapy.Therefore,individualized medication based on pharmacogenomics helps to improve cure rates,reduce relapse rates,and decrease medical costs,which is of great significance to clinical medication in mental illness.
作者
郭琦
张玲
冯媛
凌四海
阮灿军
果伟
李文标(综述)
刘辰庚
王刚(审校)
GUO Qi;ZHANG Ling;FENG Yuan;LING Sihai;RUAN Canjun;GUO Wei;LI Wenbiao;LIU Chengeng;WANG Gang(Beijing Anding Hospital,Capital Medical University/The National Medical Center for Mental Disorders/The National Clinical Research Center for Mental Disorders/Beijing Key Laboratory of Mental Disorders,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China)
出处
《国际检验医学杂志》
2025年第3期335-339,344,共6页
International Journal of Laboratory Medicine
基金
中华人民共和国科学技术部科技创新2030-“脑科学与类脑研究”重大项目(2021ZD0200600)
北京学者2021项目(063)
北京市卫生健康委员会北京市研究型病房示范建设项目(BLRW202009)
北京市属医院科研培育计划项目(PX2022077)。
关键词
精神药物
药物基因组学
临床应用
psychotropic drug
pharmacogenomics
clinical application
作者简介
通信作者:王刚,E-mail:gangwangdoc@ccmu.edu.cn。
