摘要
目的:探讨复方樟柳碱注射液对视网膜血管阻塞患者血液流变学的影响及临床疗效观察。方法:收集2020年2月—2022年7月我院眼科收治的86例视网膜血管阻塞患者为观察对象,随机分为对照组和观察组各43例。对照组予以常规治疗,观察组在对照组基础上联合复方樟柳碱注射液治疗,观察并比较两组患者的临床疗效、并发症发生情况、复发情况、治疗前后视力、血液流变学指标、血流动力学指标及血清血管生成素-2(Ang-2)水平。结果:治疗后,观察组患者总有效率为95.35%,高于对照组(P <0.05)。治疗后,观察组患者整体视力优于对照组(P<0.05),观察组患者视力≥0.7占比为44.19%,高于对照组(P<0.05)。治疗后,两组患者血液流变学各项指标水平均低于治疗前,观察组血浆黏度(1.32±0.47)m Pa·s、全血黏度(4.68±0.25)m Pa·s、红细胞比容(0.30±0.11)%、红细胞聚集指数3.78±0.42、纤维蛋白原(5.30±0.19)g/L,均低于对照组(P<0.05)。治疗后,两组患者眼动脉血管搏动指数、血清Ang-2水平均低于治疗前,且观察组动脉血管搏动指数0.53±0.16、血清Ang-2水平(2.32±0.52)ng/m L,均低于对照组(P<0.05);两组患者舒张末期流速、收缩期流速峰值、平均血流速度均高于治疗前,观察组舒张末期流速(10.41±2.59)cm/s、收缩期流速峰值(25.71±4.62)cm/s、平均血流速度(15.70±2.91)cm/s,均高于对照组(P<0.05)。治疗后,观察组不良反应发生率、复发率分别为6.98%、4.65%,均低于对照组(P<0.05)。结论:复方樟柳碱注射液应用于视网膜血管阻塞患者的治疗中,疗效显著,可有效提高患者视力,改善其血流动力学及血液流变学指标,且复发率较低,安全性高,值得临床推广应用。
Objective:This study aims to investigate the effect of compound camptothecin injection on hemorheology and clinical efficacy in patients with retinal vascular occlusion.Methods:86 patients with retinal vascular occlusion admitted to our department from February 2020 to July 2022 were collected as the observation subjects and randomly divided into a control group and an observation group,with 43 patients in each group.The control group received routine treatment,while the observation group received combined treatment with compound camptothecin injection on the basis of the control group.The clinical efficacy,incidence of complications,recurrence,as well as visual acuity,hemorheological,hemodynamic indicators,and seram angiopoietin-2(Ang-2)before and after treatment were observed and compared between the two groups of patients.Results:After treatment,the total effective rate of the observation group was 95.35%,which was higher than that of the control group(P<0.05).The overall visual acuity of the observation group patients was better than that of the control group(P<0.05),and the proportion of patients in the observation group with visual acuity≥0.7 was 44.19%,which was higher than that of the control group(P<0.05).After treatment,the levels of various indicators of hemorheology in both groups of patients were lower than before treatment,and in the observation group,plasma viscosity(1.32±0.47)mPa·s,whole blood viscosity(4.68±0.25)mPa·s,hematocrit(0.30±0.11)%,erythrocyte aggregation index 3.78±0.42,and fibrinogen(5.30±0.19)g/L were all lower than that in the control group(P<0.05).The ocular artery pulsatility index and serum Ang-2 levels in both groups of patients were lower than before treatment,and in the observation group,arterial pulsatility index 0.53±0.16,and serum Ang-2 level(2.32±0.52)ng/mL were lower than than in the control group(P<0.05).Both groups of patients had higher end diastolic flow velocity,peak systolic flow velocity,and average blood flow velocity than before treatment,and the observation group had higher end diastolic flow velocity(10.41±2.59)cm/s,peak systolic flow velocity(25.71±4.62)cm/s,and average blood flow velocity(15.70±2.91)cm/s than the control group(P<0.05).After treatment,the incidence of adverse reactions and recurrence rate in the observation group were 6.98%and 4.65%,respectively,which were lower than those in the control group(P<0.05).Conclusion:The application of compound camptothecin injection in the treatment of retinal vascular occlusion patients has significant therapeutic effects,which can effectively improve patients'vision,improve their hemodynamic and hemorheological indicators.Meanwhile,it has a low recurrence rate and high safety,which is worthy of clinical promotion and application.
作者
陈晓君
王保贞
CHEN Xiaojun;WANG Baozhen(Ophthalmology Department,the First People's Hospital of Zhengzhou,Henan,450000)
出处
《青海医药杂志》
2024年第9期1-6,共6页
Qinghai Medical Journal
关键词
视网膜血管阻塞
复方樟柳碱注射液
血液流变学
临床效果
Retinal vascular occlusion
Compound camptothecin injection
Hemorheology
Clinical efficacy
