摘要
Fangjiomics is a promising paradigm that enhances research on multi-omics-based pharmacological mechanisms of Fangji from holistic and systematic perspective.We reviewed recent advances in Fangjiomics,focusing on database and analysis platform development,methodological innovations,and translational applications.Through the integration of Fangji and multi-omics data,multi-level system analysis approaches were developed,encompassing single-target analysis,signaling pathways,multi-targeted network and modules.Fangjiomics has emerged as a key strategy in various areas of Fangji research.To support the high quality development of Fangjiomics,we propose principles and perspectives from the integrated,macro-level,and practical viewpoints.
方剂组学作为一种新兴的研究范式,从整体和系统的角度探索了基于多组学的方剂药理机制的研究。本文回顾了方剂组学的最新进展,重点介绍了相关数据库和分析平台、方法创新及转化应用。通过整合方剂和多组学数据,研究者从单靶点分析、信号通路、多靶点网络和靶点模块等角度构建了多层次系统解析方法。方剂组学已成为方剂研究各个领域的重要策略,本文并从综合、宏观和实践的角度提出了方剂组学高质量发展原则和展望。
基金
National Key Research and Development Project(2023YFC3502903)
National Natural Science Foundation of China(82474376)
Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2023C063YLL).
作者简介
李兵,contributed equally;赵钰文,contributed equally;Corresponding author:王忠,E-mail:zhonw@vip.sina.com.
