摘要
异噁唑啉类药物具有多种功效。近年来,因其对各种类型体外寄生虫的疗效好、安全性高,被广泛应用于抗宠物体外寄生虫。异噁唑啉类药物选择性地抑制无脊椎动物的谷氨酸和γ-氨基丁酸门控氯离子通道,使其神经系统紊乱而瘫痪死亡。本文从结构特点、作用机制、药代动力学、药效学和临床驱虫应用等方面综述了异噁唑啉类驱虫药近年来的研究,分析了兽医领域中不同药物的应用情况及潜在毒性,展望异噁唑啉类动物驱虫药的未来发展情况。
Isoxazoline drugs have a variety of biological effects.In recent years,they have been widely used in pet to combat ectoparasites due to their excellent effectiveness and high safety against various types of ectoparasites.Isoxazoline drugs selectively inhibits glutamate and gamma-aminobutyrate gated chloride ion channels in invertebrates,resulting in nervous system dysfunction,paralysis and death.This review focuses on the structural characteristics,mechanism of action,pharmacokinetics,pharmacodynamics and clinical anthelmintic application of isoxazoline anthelmintic drugs in recent years.The application and potential toxicity of different drugs in veterinary medicine are analyzed,and presents the future prospect of isoxazoline anthelmintics in animals.
作者
王达锋
马叶涵
陈春
龚佳豪
四朗玉珍
张军忍
郭大伟
WANG Dafeng;MA Yehan;CHEN Chun;GONG Jiahao;SILANG Yuzhen;ZHANG Junren;GUO Dawei(College of Veterinary Medicine,Nanjing Agricultural University,Nanjing 210095,China;Animal Science and Technology College,Beijing University of Agriculture,Beijing 102206,China;Nanjing Petmed Tech Technology Co.,Ltd,Nanjing 210031,China;Grassland Science Research Institute,Tibet Academy of Agriculture and Animal Husbandry Sciences,Lasa 850000,China)
出处
《畜牧兽医学报》
北大核心
2025年第1期126-135,共10页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
西藏自治区区域科技协同创新专项(QYXTZX-RKZ2024-03-2)
中央高校基本科研业务费(KYCXJC2024002)。
作者简介
王达锋(2002-),男,广东汕头人,主要从事兽药新制剂研究,E-mail:15380807276@163.com;通信作者:郭大伟,主要从事兽医药理和药剂学研究,E-mail:gdawei0123@njau.edu.cn。
