摘要
目的:探讨化湿降浊排毒法中西医结合治疗对湿浊型慢性肾脏病3~5期非透析患者的临床疗效。方法:将64例慢性肾脏病3~5期的非透析患者随机分为干预组31例(脱落1例)和对照组31例(脱落1例)。对照组进行西医常规治疗;干预组在西医常规治疗基础上,加用中医化湿降浊排毒法辨证治疗。比较两组治疗8周前后的临床疗效,包括血肌酐(Scr)、估算肾小球滤过率(eGFR)、尿素氮(BUN)、二氧化碳结合力(CO 2CP)、尿酸(UA)、胱抑素-c(Cys-c)、24 h尿蛋白定量(UAER)、血红蛋白(Hb)、血清白蛋白(Alb)、甲状旁腺激素(PTH)、β2-微球蛋白(β2-MG)等指标的变化以及中医证候积分、中医临床疗效的变化。结果:在治疗8周后,干预组的中医临床疗效总有效率93.5%,对照组为87.1%。两组的Scr、eGFR、BUN、UA、Cys-c、UAER、Hb、Alb、PTH、中医证候积分的改善情况差异有统计学意义(P<0.05),干预组的β2-MG指标较治疗前改善差异具有统计学意义(P<0.05),且干预组的Scr、eGFR、Cys-c、UAER、Hb、Alb、中医证候积分的改善效果较对照组更好(P<0.05)。结论:中医化湿降浊排毒法中西医结合治疗对湿浊型慢性肾脏病3~5期非透析患者的疗效确切,能改善患者的临床症状。
Objective:To investigate the clinical efficacy of Huashi Jiangzhuo Paidu Therapy combined with traditional Chinese medicine(TCM)and Western medicine on patients with chronic kidney disease stage 3~5 due to damp-turbidity.Methods:Sixty-four patients with nondialysis CKD stage 3~5 were randomly divided into intervention group(31 cases)and control group(31 cases).The control group was treated with conventional western medicine;the intervention group was treated with TCM dialectical therapy of Huashi Jiangzhuo Paidu Therapy on the basis of the control group.The clinical efficacy of the two groups before and after 8 weeks of treatment was compared,including changes in Scr、eGFR、BUN、Cys-c、CO2cp、UA、UAER、Hb、ALB、PTH、β2-MG、TCM syndrome score、TCM syndrome efficacy.Results:After the treatment,the total effective rate of TCM clinical efficacy in the intervention group was 93.5%,and that in the control group was 87.1%.The extents of improvement of Scr、eGFR、BUN、Cys-c、UA、UAER、Hb、Alb、PTH、TCM syndrome score in the two groups were statistically significant(P<0.05),among which the improvement of Scr、eGFR、Cys-c、UAER、Hb、Alb、TCM syndrome score of the intervention group were better than those in the control group(P<0.05).And the extents of improvement ofβ2-MG indexes in the intervention group was statistically different from before.Conclusion:For the patients of nondialysis CKD stage 3~5 due to damp-turbidity,Huashi Jiangzhuo Paidu Therapy combined with Chinese medicine and Western medicine treatment can improve the clinical symptoms of patients.
作者
马晓彤
翁俊雄
龚保文
MA Xiaotong;WENG Junxiong;GONG Baowen(Shantou Hospital of Traditional Chinese Medicine of Guangzhou University of Chinese Medicine,Shantou 515000)
出处
《中国中西医结合肾病杂志》
2024年第11期962-965,共4页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
龚保文汕头市名中医传承工作室项目(No.汕市卫办[2020]60号)。
关键词
化湿降浊排毒法
慢性肾脏病
湿浊证
临床研究
Huashi Jiangzhuo paidu therapy
Chronic kidney disease
Damp-turbidity
Clinical research
