摘要
目的探究芩桑清热化痰汤用于痰热郁肺证慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床疗效。方法选取2023年1月至2024年1月收治的150例痰热郁肺证AECOPD患者,随机平均分为对照组与观察组。对照组常规西药治疗,观察组芩桑清热化痰汤联合常规西药治疗。比较2组临床疗效、气道黏液高分泌指标及不良反应发生情况,并对2组治疗前后中医证候积分、肺功能、痰液炎性因子和细胞总数进行比较。结果观察组临床总有效率为92.00%(69/75),高于对照组的80.00%(60/75,P<0.05)。治疗后,观察组痰液白细胞介素-8、肿瘤坏死因子-α和细胞总数以及各项中医证候积分均低于对照组,第1秒用力呼气容积、第1秒用力呼气容积/用力肺活量、第1秒用力呼气容积占预计值百分比均高于对照组(P<0.05)。治疗后,观察组痰色、痰质及痰量评分均低于对照组(P<0.05)。治疗期间,2组总不良反应发生率比较无统计学差异(P>0.05)。结论芩桑清热化痰汤能显著改善痰热郁肺证AECOPD患者的症状,提高肺功能,减少痰液中的炎性细胞,且对痰液性状改善具有显著效果,是一种有效的辅助治疗方法,能够增强常规西药疗效。
Objective To explore the clinical effect of Qinsang Qingre Huatan decoction in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with phlegm-heat stagnation lung syndrome.Methods A total of 150 AECOPD patients with phlegm-heat stagnation lung syndrome admitted from January 2023 to January 2024 were randomly divided into control group(n=75)and observation group(n=75).The control group received conventional Western medicine treatment,and the observation group received Qinsang Qingre Huatan decoction combined with conventional Western medicine treatment.The clinical efficacy,airway mucus hypersecretion index and the occurrence of adverse reactions were compared between the two groups,and the traditional Chinese medicine(TCM)syndrome score,pulmonary function,sputum inflammatory factors and the total number of cells before and after treatment were compared between the two groups.Results The total clinical effective rate of the observation group was 92.00%(69/75),which was higher than that of the control group[80.00%(60/75)](P<0.05).After treatment,the sputum interleukin-8,tumor necrosis factor-α,the total number of cells and various TCM syndrome scores in the observation group were lower than those in the control group,whereas the percentage of forced expiratory volume in the first second,forced expiratory volume in the first second/forced lung capacity,and forced expiratory volume in the first second in the predicted value were higher than those in the control group(P<0.05).After treatment,the scores of sputum color,sputum quality and sputum volume in observation group were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Qinsang Qingre Huatan decoction can significantly improve the symptoms of AECOPD patients with phlegm-heat stagnation lung syndrome,improve pulmonary function,reduce the inflammatory cells in sputum,and has a significant effect on the improvement of sputum properties,which is an effective adjuvant treatment method,and can enhance the efficacy of conventional Western medicine.
作者
张萱
观云
段明明
张娜娜
施保柱
ZHANG Xuan;GUAN Yun;DUAN Mingming;ZHANG Nana;SHI Baozhu(Department of Respiratory Intensive Care,Hebei Hospital of Traditional Chinese Medicine,Shijiazhuang 050000,China)
出处
《临床误诊误治》
2025年第1期91-95,共5页
Clinical Misdiagnosis & Mistherapy
基金
河北省中医药管理局科研计划项目(2021081)
2024年政府资助临床医学优秀人才培养项目(ZF2024158)
河北省中医药管理局2022年度中医类科研计划项目(2022023)。
关键词
慢性阻塞性肺疾病
急性加重期
痰热郁肺证
芩桑清热化痰汤
肺功能
白细胞介素-8
肿瘤坏死因子-Α
不良反应
Chronic obstructive pulmonary disease
Acute exacerbations
Phlegm-heat stagnation lung syndrome
Qinsang Qingre Huatan decoction
Pulmonary function
Interleukin-8
Tumour necrosis factor-α
Adverse reaction
作者简介
张萱,硕士研究生,主治医师。主要从事中西医结合治疗呼吸系统常见疾病方向研究;通讯作者:施保柱,E-mail:shbzh0088@163.com。
