摘要
目的 评价注射用阿奇霉素治疗呼吸道感染的疗效与安全性。方法 利用随机对照研究方法 ,将 71例轻中度呼吸道感染病人随机分为两组。试验组用阿奇霉素治疗 ,首次 5 0 0 mg,每天 1次 ,以后用2 5 0 mg,每天 1次静脉滴注 ,疗程共 5 d。对照组用红霉素治疗 ,每天 10 0 0～ 12 5 0 mg,每天 1次 ,静脉滴注 ,疗程7～ 10 d。结果 两药的临床疗效和细菌学疗效相似 ,但试验药不良反应发生率低 ,试验组不良反应发生率为8.5 7% ,对照组 2 7.78%。
Objective To evaluate the efficacy and safety of azithromycin in the treatment of respiratory tract infection. Methods 71 patients were divided into 2 groups randomly. The treatment group were given azithromycin 0 5 g iv drip, for the first day, then 0 25g iv drip qd for 4d. The control group were given erythromycin 1～1 25g iv drip qd for 7～10d. Result There was no significant statistics difference between two groups on clinical cure rates and bacterial eradication rates ( P >0 05). but the side effect rates in the treatment groups and the control group was 8 57% and 27 78%, respectively. There was a significant difference between two groups ( P <0 05). Conclusion Azithromycin was an effective and safe agent for the treatment of respiratory tract infection.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2002年第12期745-747,共3页
Chinese Journal of Antibiotics
