摘要
目的 建立一种操作简单、切实可行的实验性眩晕动物模型 ,以便于抗眩晕药物的研究。方法 选用昆明种小鼠 ,通过训练使其建立起逃避电击反射 ,然后通过旋转使动物产生眩晕 ,以旋转后逃避电击反射完成所需的时间 (潜伏期 )作为衡量眩晕时间长短的指标。结果 用天麻素、盐酸地芬尼多及对照组对该方法进行验证。结果显示 ,该模型能有效地反映以上抗眩晕药物及对照组的药效作用。结论 该模型能够很好地反映动物眩晕程度及眩晕时间的变化 。
AIM To establish a practical animal model of experimental vertigo. The model can be used for the study of the anti-vertigo drugs. METHODS To choose the healthy mice. Firstly,to set up the reflex of escaping lightening stroke by trained mouse; secondly,to make it vertiginous by rotation. The vertigo period is the latent period which is the time of to fulfill the reflex of escaping lightening stroke after the rotation. RESULTS We proved the model effectiveness on gastrodine,diphenidol hydrochloride and the control. The results showed that the model could reflect the potency of the anti-vertigo drugs and the control mentioned above. CONCLUSION The model is successful,easy to operate,stable,and reliable. This can reflect well the variation of vertigo level and vertigo period of animal,which can be effectively used in the research of the anti-vertigo drugs.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2002年第6期518-520,共3页
Journal of China Pharmaceutical University
关键词
实验性眩晕
动物模型
逃避电击反射
潜伏期
眩晕时间
Animal model of experimental vertigo
Reflex of escaping lightening stroke
Latent period
Vertigo period
