摘要
目的 评价超声造影剂Levovist对彩色多普勒血流显像 (彩超 )检测肿瘤血管的增强效应 ,探讨其在诊断卵巢癌盆腔复发灶中的应用价值。方法 应用彩超检查 6例卵巢癌盆腔复发灶 ,比较注射Levovist前后病灶内血管显像情况以及多普勒信号增强情况 ,并建立ROC曲线。同时测定其血清CA12 5。结果 卵巢癌复发灶造影后彩色多普勒血流信号明显增强 ,并显示特征性的血管形态 ,血管数目明显增多 ,血管扭曲度增加。ROC曲线显示 :造影后多普勒信号增强开始时间≤5 0s、到达高峰时间≤ 10 0s、持续时间≥ 5 5 0s时 ,复发灶的敏感性、特异性最高。结论 Levovist的应用有助彩超更准确地评价肿瘤的血供情况 ,与妇科检查、常规彩超、血清CA12 5结合可早期诊断卵巢癌盆腔复发灶 ,为临床诊断、治疗和随访提供一定帮助。
Objective To assess the efficacy of ultrasound contrast agent Levovist in evaluating vascularization of recurrence of ovarian cancer in pelvis. Methods Six recurrences of ovarian cancer were submitted to color Doppler flow imaging (CDFI) before and after i.v.Levovist,and then their vascularization and enhancement of Doppler signal were compared.Receiver operator characteristic curves were established.In addition,all patients' serum CA125 level were determined. Results After contrast,color Doppler signals in recurrences of ovarian cancer were enhanced obviously and characteristic vessel morphology were observed.Vessel numbers and tortuosity increased.ROC curves showed that the sensitivity and specificity were the highest when the time to commencement was ≤50s,time to peak ≤100s and duration of enhancement ≥550s. Conclusion Levovist increases the intensity of color Doppler signals obviously,and allows a more complete display of the vascular patterns of recurrence of ovarian cancer.It improves markedly the role of CDFI in diagnosis of recurrence of ovarian cancer.
出处
《中国医学影像技术》
CSCD
2002年第10期1057-1060,共4页
Chinese Journal of Medical Imaging Technology
