摘要
成功的抗凝是保障连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)顺利实施的关键,国内外相关指南一致推荐局部枸橼酸抗凝作为首选。既往临床使用的传统局部枸橼酸抗凝剂操作复杂,并有电解质紊乱及酸碱失衡的潜在风险,导致局部枸橼酸抗凝临床普及受阻。新型枸橼酸盐置换液作为血液滤过置换液的同时,兼具抗凝功效,它的出现弥补了既往局部枸橼酸抗凝剂的不足。本文从抗凝效果、治疗效率、安全性等角度对枸橼酸盐置换液相关临床研究进行综述,以期对其发展及现状进行全面的介绍,并为临床应用提供理论支持。
Anticoagulation strategy ensures filter patency and delivery of an adequate continuous renal replacement therapy(CRRT)dose.Most guidelines recommend the regional citrate anticoagulation(RCA)as the first-line method for patients requiring CRRT.Previous use of the traditional regional citrate anticoagula-tion had several drawbacks such as complex operation,risks of acid-base imbalance and metabolic disorders,leading to the restriction of its clinical applications.By contrast,citrate-based replacement fluids solve these deficiencies.This article reviews the research progress in citrate-based replacement fluids from point of view of anticoagulation effectiveness,treatment efficiency and security.
作者
童双
林乔轩
王敏敏
王磊
TONG Shuang;LIN Qiao-xuan;WANG Min-min;WANG Lei(Department of Medical Affairs and Clinical Development,Baxter China Ltd,Shanghai 200031,China;Department of Nephrology,Peking University People's Hospital,Beijing 100044,China)
出处
《中国血液净化》
2025年第1期49-53,共5页
Chinese Journal of Blood Purification
关键词
连续性肾脏替代治疗
局部枸橼酸抗凝
枸橼酸盐置换液
Continuous renal replacement therapy
Regional citrate anticoagulation
Citrate-based replacement fluid
作者简介
通讯作者:王磊,Email:bjwangl@163.com。
