摘要
垂体神经内分泌肿瘤(pituitary neuroendocrine tumors, PitNETs)的治疗虽然随着神经内镜技术的发展取得了显著进展, 但部分难治性PitNETs仍面临侵袭性强、难以全切和易复发等挑战, 现有治疗手段难以获得理想预后。免疫治疗作为一种新兴的治疗方式, 通过激活机体免疫系统来增强抗肿瘤免疫应答, 为难治性PitNETs的治疗提供了新的可能。近年来, 单细胞测序技术的应用揭示了PitNETs的肿瘤异质性和免疫微环境特征, 为免疫治疗在PitNETs中的应用提供了理论基础。研究发现, 不同PitNETs亚群存在不同程度的免疫浸润, 这一发现为靶向免疫治疗策略的开发提供了重要线索。然而, 目前PitNETs的免疫治疗研究仍面临诸多挑战, 包括缺乏充分验证的免疫治疗靶点、临床试验数量有限、治疗方式单一以及疗效不确定等问题。为推进PitNETs的免疫治疗研究, 未来需要通过多组学分析深入挖掘潜在免疫治疗靶点, 同时开展更多基础研究和临床试验, 探索多样化的免疫治疗策略, 并致力于建立个体化治疗方案和联合治疗模式。
Despite advancements in endoscopic treatment for pituitary neuroendocrine tumors(PitNETs),refractory PitNETs remain challenging due to their invasiveness,incomplete resection,and recurrence,with suboptimal outcomes from current therapeutic modalities.Immunotherapy,which enhances anti-tumor immune responses,presents a promising approach for managing refractory PitNETs.Single-cell sequencing has recently revealed tumor heterogeneity and immune microenvironment characteristics of PitNETs,providing a foundation for immunotherapy applications.Studies have revealed that immune infiltration varies across PitNET subgroups,offering insights for targeted immunotherapy.However,challenges persist,including a lack of validated immunotherapeutic targets,limited clinical trials,monotonous approaches,and uncertain efficacy.Future research should prioritize multiomics analyses to identify new targets,expand basic and clinical research,explore diverse immunotherapeutic strategies,and develop personalized and combination therapies.
作者
林绍坚
吴隽宸
吴哲褒
Lin Shaojian;Wu Junchen;Wu Zhebao(Department of Neurosurgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2024年第11期920-922,共3页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金(82141114, 82373131)。
关键词
垂体神经内分泌肿瘤
免疫治疗
肿瘤异质性
免疫微环境
多组学分析
Pituitary neuroendocrine tumors
Immunotherapy
Tumor heterogeneity
Immune microenvironment
Multi-omics analyses
作者简介
通信作者:吴哲褒,Email:zhebaowu@aliyun.com。
