摘要
糖尿病肾脏病(DKD)是糖尿病(DM)严重微血管并发症之一,也是进展为终末期肾病(ESRD)的主要原因,目前尚无根治办法,是亟待解决的医学难题。“过甘伤肾”出自《素问·生气通天论》“味过于甘,心气喘满,色黑,肾气不衡”,指出甘味过极损伤肾气。细胞焦亡作为细胞程序性死亡方式之一,通过激活炎性小体诱导肾脏细胞焦亡参与DKD发生发展。本文将通过探讨“过甘伤肾”理论与细胞焦亡的联系及其视角下高糖与DKD的关系,以期为中医药防治DKD提供理论依据及新思路。
Diabetic kidney disease(DKD)is one of the serious microvascular complications of diabetes mellitus(DM)and the main cause of progression to end-stage renal disease(ESRD)."Excessive sweets damaging kidney"comes from the chapter of Discussion on Interrelationship between Life and Nature in Basic Questions:"excessive taking of sweet makes heart qi stuffy,the complexion blackish,and kidney qi imbalanced",which points out that excessive taking of sweet damages kidney qi.As one of the programmed cell death modes,pyroptosis is involved in the occurrence and development of DKD,which is based on the induction of pyroptosis in kidney by activating inflammasomes.This paper delves into the relationship between the theory of"excessive taking of sweet damaging kidney"and pyroptosis and,from the perspective of pyroptosis,the relationship between high glucose and DKD,in order to provide theory basis and new ideas for the prevention and treatment of DKD by traditional Chinese medicine.
作者
张芸
杨亚丽
朱晓琳
殷立平
ZHANG Yun;YANG Yali;ZHU Xiaolin;YIN Liping(Nephrology Department,The Second Affiliated Hospital of Nanjing University of Chinese Medicine/Jiangsu Second Chinese Medicine Hospital,Nanjing 210017,China)
出处
《基层中医药》
2024年第11期46-51,共6页
Basic Traditional Chinese Medicine
基金
国家自然科学基金青年科学基金资助项目(82104754)
国家中医临床研究基地开放课题(JD2023SZ15)。
关键词
糖尿病肾脏病
过甘伤肾
细胞焦亡
高血糖
炎症因子
diabetic kidney disease
excessive taking of sweet damaging kidney
pyroptosis
high glucose
inflammatory factors
作者简介
通信作者:殷立平,E-mail:Yinlipingo03@aliyun.com。
