摘要
贻贝黏蛋白(MAP)因其包含丰富的赖氨酸、多巴胺和疏水基团,可针对性应用于当前皮肤和黏膜组织的各种适应证,在医疗领域展现出巨大潜力。该文深入探讨了这些蛋白的结构、合成生物学工具在其表达和生物制造中的应用,以及临床研究的最新进展,并从产品分类、注册、行业标准等角度分析了医疗行业相关政策,以便了解其发展现状,为扩展临床应用提供参考。
Mussel mucin(MAP),due to its rich lysine,dopamine and hydrophobic groups,can be targeted for various indications applied to current skin and mucosal tissues and shows great potential in the medical field.This article outlines the structure of these proteins,the recent advancement of protein expression and biomanufacturing using various synthetic biology tools,and the status of relevant clinical research.This paper deeply explores the structure of these proteins,application of synthetic biology tools in their expression and biofabrication and the latest progress in clinical research,and analyzes the related policy in the medical industry from the angles of the products,classification,registration and industrial standard in order to understand its development status quo and provide reference for extending the clinical application.
作者
邹勇
王兴凯
安柏霖
赵裕栋
ZOU Yong;WANG Xingkai;AN Bolin;ZHAO Yudong(China Resources Pharmaceutical Commercial Group Medical Device Co.,Ltd.,Beijing 100070,China;Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong 518055,China;Shenzhen Baiyin Biotechnology Co.,Ltd.,Shenzhen,Guangdong 518107,China)
出处
《重庆医学》
CAS
2024年第24期3810-3814,共5页
Chongqing Medical Journal
基金
国家自然科学基金青年项目(32201105)。
关键词
贻贝黏蛋白
多巴
合成生物技术
综述
mussel adhesive protein
dopa
synthetic biological technology
review
