摘要
目的探究腹腔镜下离断性肾盂成形术对肾盂输尿管连接部狭窄患儿临床疗效及血清白介素⁃6(IL⁃6)、肿瘤坏死因子⁃α(TNF⁃α)及C⁃反应蛋白(CRP)水平的影响。方法选取2021年6月至2023年5月河南省儿童医院收治的肾盂输尿管连接部狭窄患儿93例为研究对象,并根据治疗方法的差异分为对照组46例(开放离断性肾盂成形术)与观察组47例(腹腔镜下离断性肾盂成形术)。比较两组治疗疗效、临床指标[手术时间、术中出血量、术后肠胃功能恢复时间、住院时间]、炎性因子水平[IL⁃6、TNF⁃α、CRP]、并发症发生情况以及复发率。结果观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。观察组手术时间、术后肠胃功能恢复时间、住院时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05)。治疗后,两组IL⁃6、TNF⁃α、CRP水平呈升高趋势,且观察组水平均比对照组低,差异有统计学意义(P<0.05)。观察组并发症发生率(2.13%)显著低于对照组(13.04%),差异有统计学意义(P<0.05)。结论腹腔镜离断式肾盂成形术可有效提高肾盂输尿管连接部狭窄患儿的临床疗效、安全性,有效改善患儿炎症水平,促进患儿恢复。
Objective To explore the effect of laparoscopic dismembered pyeloplasty on the clini⁃cal efficacy and serum levels of interleukin⁃6(IL⁃6),tumor necrosis factor⁃α(TNF⁃α)and C⁃reactive protein(CRP)in children with ureteropelvic junction stenosis.Methods A total of 93 patients with ureteropelvic junction stenosis were admitted to Henan Childrens Hospital from June 2021 to May 2023 were selected as the research subjects.Based on the difference in treatment methods,they were divided into two groups:the con⁃trol group(46 cases,open dismembered pyeloplasty)and the observation group(47 cases,laparoscopic dis⁃membered pyeloplasty).The therapeutic effects,clinical indicators(such as operation time,intraoperative blood loss,postoperative gastrointestinal function recovery time,hospitalization time),inflammatory factor levels(IL⁃6,TNF⁃α,CRP),complications and recurrence rates were compared between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The operation time,postoperative gastrointestinal function recovery time and hospitalization time in the observation group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group,the differences were statisti⁃cally significant(P<0.05).After treatment,the levels of IL⁃6,TNF⁃α,and CRP in the two groups showed an increasing trend,and the levels in the observation group were lower than those in the control group,the differ⁃ences were statistically significant(P<0.05).The incidence of complications in the observation group(2.13%)was significantly lower than that in the control group(13.04%),and the difference was statistically significant(P<0.05).Conclusion Laparoscopic dismembered pyeloplasty can effectively enhance the clinical efficacy and safety for children with ureteropelvic junction stenosis.It can also improve the level of inflammation in children,and promote their recovery.
作者
曹亚青
李莹
丁碧玉
张晓丹
韩鑫鑫
CAO Yaqing;LI Ying;DING Biyu;ZHANG Xiaodan;HAN Xinxin(Department of Urology,Henan Children's Hospital,Zhengzhou Children's Hospital,Zhengzhou,Henan,China,450000)
出处
《分子诊断与治疗杂志》
2024年第12期2307-2310,共4页
Journal of Molecular Diagnostics and Therapy
基金
河南省科技发展计划项目(182102310413)。
作者简介
通信作者:曹亚青,E⁃mail:15039061528@163.com。
