摘要
目的探讨消化内镜黏膜下剥离术治疗早期食管癌的疗效。方法随机选取2021年3月—2024年3月福建省福清市医院收治的100例早期食管癌患者为研究对象,按照手术方法不同分为研究组、对照组,每组50例。对照组采取内镜分片黏膜切除术治疗,研究组应用消化内镜黏膜下剥离术治疗,对比两组肿瘤标志物水平、临床相关指标、并发症发生情况。结果术后,两组癌胚抗原、血管内皮生长因子、糖类抗原19-9、多巴胺脱羧酶水平均低于术前,且研究组低于对照组,差异均有统计学意义(P均<0.05)。研究组手术时间(0.36±0.07)h、出血量(86.29±8.32)mL、住院时间(4.49±1.22)d、剥离面积(10.50±2.07)cm^(2)、单位时间切除率(18.70±3.26)mm^(2)/min均优于对照组的(1.49±0.22)h、(121.29±14.16)mL、(9.01±2.24)d、(7.59±1.21)cm^(2)、(12.22±2.10)mm^(2)/min,差异均有统计学意义(t=34.610,15.069,12.530,8.582,11.816;P均<0.05)。研究组并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论消化内镜黏膜下剥离术的应用,对降低早期食管癌患者并发症发生率作用显著,在减少剥离面积,降低术后肿瘤标志物水平方面优势突出。
Objective To investigate the efficacy of gastrointestinal endoscopic submucosal dissection in the treatment of early esophageal cancer.Methods A total of 100 patients with early esophageal cancer admitted to Fujian Fuqing City Hospital from March 2021 to March 2024 were randomly selected as the research objects.According to different surgical methods,they were divided into study group and control group,with 50 cases in each group.The control group was treated with endoscopic mucosal resection,and the study group was treated with gastrointestinal endoscopic submucosal dissection.The levels of tumor markers,clinical related indicators and complications were compared be-tween the two groups.Results After operation,the levels of carcinoembryonic antigen,vascular endothelial growth fac-tor,carbohydrate antigen 19-9 and dopamine decarboxylase in the two groups were lower than those before operation,and those in the study group were lower than the control group,the differences were statistically significant(all P<0.05).The operation time(0.36±0.07)h,bleeding volume(86.29±8.32)mL,hospitalization time(4.49±1.22)d,strip-ping area(10.50±2.07)cm^(2),and resection rate per unit time(18.70±3.26)mm^(2)/min in the study group were better than those in the control group(1.49±0.22)h,(121.29±14.16)mL,(9.01±2.24)d,(7.59±1.21)cm^(2),(12.22±2.10)mm^(2)/min,the differences were statistically significant(t=34.610,15.069,12.530,8.582,11.816;all P<0.05).The total incidence of complications in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The application of digestive endoscopic submucosal dissection has a significant effect on reduc-ing the incidence of complications in patients with early esophageal cancer.It has outstanding advantages in reducing the area of dissection and reducing the level of postoperative tumor markers.
作者
王敏
程伟
WANG Min;CHENG Wei(Fujian Fuqing City Hospital,Fuqing,Fujian,350300,China)
出处
《中外医疗》
2024年第34期66-69,共4页
China & Foreign Medical Treatment
关键词
早期食管癌
消化内镜黏膜下剥离术
肿瘤标志物
Early esophageal cancer
Gastrointestinal endoscopic submucosal dissection
Tumor markers
作者简介
王敏(1971-),男,本科,副主任医师,研究方向为经内镜食管、胃、结肠剥离术。
