摘要
外泌体是一种可以被多种细胞分泌,在血液、尿液等体液标本中广泛存在的囊泡。在呼吸系统疾病的发展过程中,上皮和免疫细胞来源的外泌体可以分泌RNA、蛋白质等物质破坏呼吸系统防御体系,诱导或加重疾病。循环外泌体和肺脏组织来源外泌体可以作为呼吸系统疾病的潜在诊断标志物,大大提高了对肿瘤、感染等呼吸系统疾病的诊断灵敏度及特异性。呼吸系统疾病的治疗也与外泌体密切相关。外泌体的低免疫源性、高相容性使其成为递送分子、药物进行治疗的有效工具。
Exosomes are extracellular vesicles that can be secreted by various cells and widely exist in body fluids such as blood and urine.During the progression of respiratory tract diseases,exosomes derived from epithelial and immune cells can secrete substances such as RNA and proteins,disrupting the respiratory defense system and inducing or exacerbating the disease.Exosomes derived from circulating and lung tissues can be used as potential diagnostic markers for respiratory diseases,which greatly improves the diagnostic sensitivity and specificity for respiratory diseases such as tumors and infections.The treatment of respiratory diseases is also closely related to exosomes.The low immunogenicity and high compatibility of exosomes make them effective tools for delivering molecules and drugs for treatment.
作者
高弋婷
卜欣阳
杜曼昕
刘家云
张翔
GAO Yiting;BU Xinyang;DU Manxin;LIU Jiayun;ZHANG Xiang(Department of Clinical Laboratory,Xijing Hospital,2Regiment Four of Cadets,3Regiment One of Cadets,Basic Medical Science Academy,Air Force Medical University,Xi’an 710032,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2024年第11期1044-1049,共6页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金(81903145,81972026)
陕西省重点研发计划项目(2021ZDLSF06-06)。
关键词
外泌体
呼吸道疾病
诊断
治疗
综述
exosomes
respiratory tract diseases
diagnosis
therapeutics
review
作者简介
第一作者:高弋婷(2002-),女,陕西榆林人,本科生,Tel:15909202832,E-mail:1723181291@qq.com;第一作者:卜欣阳;通讯作者:张翔,E-mail:cicixiangz@163.com;通讯作者:刘家云,E-mail:jiayun@163.com。
