摘要
Objectives:This study aimed to investigate the protective effects and underlying mechanisms of aerobic intermittent exercise on cognitive impairment by PM_(2.5)exposure.Methods:Thirty-two rats were randomly divided into four groups:sedentary,exercise,sedentary+PM_(2.5)exposure,and exercise+PM_(2.5)exposure.The exercise groups underwent 8 weeks of exercise training(5 days of exercise per week).Subsequently,PM_(2.5)exposure groups were subjected to PM_(2.5)for three weeks.Post-exposure,we assessed cognitive abilities(shuttle box test),hippocampal tissue structure,related inflammatory factors(TNF-α,IL-6,IL-1β),the protein of inflammatory responses mechanism(P65,IκκB)and cognitiverelated protein levels(BDNF,Aβ-42).Results:PM_(2.5)exposure caused cognitive impairment,abnormal histopathological changes,reduced cognitive related protein and increased pro-inflammatory cytokine levels.Analysis of shuttle box test data revealed significant main effects on the passive avoidance latency times measured in rats(p<0.05).Aerobic intermittent exercise improves spatial learning decline in rats induced by PM_(2.5).Conversely,the Exercise+PM_(2.5)group demonstrated a significant reduction in latency of 24.9%compared to the Sedentary+PM_(2.5)group(p<0.05,ES=1.41).Conclustion:Aerobic intermittent exercise may help in protecting against the decrease of cognitive ability induced by PM_(2.5)exposure.
作者简介
first authorship:Zhongwei Wang have contributed equally to this workfirst authorship;Fei Qin have contributed equally to this workCorresponding author:Jiexiu Zhao,PhD,Professor,Exercise BiologicalCenter,China Institute of Sport Science,No.11 Stadium Road,DongchengDistrict,100061,Beijing,China,E-mail:zhaojiexiu@ciss.cnZhongwei Wang and Dongzhe Wu,Exercise Biological Center,ChinaInstitute of Sport Science,Beijing,ChinaFei Qin,School of Physical Education,Jinan University,Guangzhou,ChinaMinxiao Xu,Exercise Biological Center,China Institute of Sport Science,Beijing,China,and Institute of Physical Education and Training,CapitalUniversity of Physical Education and Sports,Beijing,ChinaShuqiang Cui,Exercise Biological Center,China Institute of Sport Science,Beijing,China,and Athletic Sports Research Lab,Beijing Institute of SportsScience,Beijing,China。
