摘要
目的 观察幽门螺杆菌感染对妊娠期糖尿病患者血糖、血脂的影响。方法 84例妊娠期糖尿病患者,根据是否发生幽门螺杆菌感染分成对照组(未发生感染)和研究组(发生感染),每组42例。比较两组的血糖指标[空腹血糖、餐后2 h血糖、糖化血红蛋白]、血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]、妊娠结局。结果 研究组空腹血糖、餐后2 h血糖、糖化血红蛋白、TC、TG、LDL-C水平分别为(8.48±2.04)mmol/L、(10.68±2.27)mmol/L、(8.76±1.33)%、(6.71±1.32)mmol/L、(3.43±0.58)mmol/L、(3.53±0.53)mmol/L,均高于对照组的(7.28±1.18)mmol/L、(8.60±1.20)mmol/L、(7.35±0.96)%、(3.05±0.74)mmol/L、(2.27±0.31)mmol/L、(2.83±0.55)mmol/L,两组比较差异明显,具有统计学意义(P<0.05)。研究组剖宫产、先兆子痫、产后出血、新生儿呼吸窘迫综合征、巨大儿、低体重儿发生率分别为52.38%、19.05%、21.43%、19.05%、19.05%、21.43%,均高于对照组的30.95%、2.38%、4.76%、2.38%、2.38%、2.38%,两组比较差异明显,具有统计学意义(P<0.05)。结论 在妊娠期糖尿病患者中,感染幽门螺杆菌后对其血糖与血脂水平影响较大,且剖宫产率增加,先兆子痫、产后出血、新生儿呼吸窘迫综合征、巨大儿、低体重儿发生率亦显著升高。因此对于妊娠期糖尿病患者,应早期开展幽门螺杆菌筛查,明确其感染情况,以实施早期干预,进而改善妊娠结局。
Objective To observe the effect of Helicobacter pylori infection on blood glucose and lipids in women with gestational diabete.Methods 84 cases of women with gestational diabetes were selected.According to whether there was Helicobacter pylori infection,they were divided into a control group(with infection) and a study group(without infection),with 42 cases in each group.The blood glucose indicators [fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin],blood lipid indicators [total cholesterol(TC),triglycerides(TG),low density lipoprotein cholesterol(LDL-C)] and pregnancy outcome were compared between the two groups.Results In the study group,the fasting blood glucose,2 h postprandial glucose,glycated hemoglobin,TC,TG and LDL-C were(8.48±2.04) mmol/L,(10.68±2.27) mmol/L,(8.76±1.33) %,(6.71±1.32) mmol/L,(3.43±0.58) mmol/L and(3.53±0.53) mmol/L,which were higher than(7.28±1.18) mmol/L,(8.60±1.20) mmol/L,(7.35±0.96) %,(3.05±0.74) mmol/L,(2.27±0.31) mmol/L and(2.83±0.55) mmol/L in the control group,and there were significant differences between the two groups(P<0.05).In the study group,the incidence of cesarean section,pre-eclampsia,postpartum hemorrhage,neonatal respiratory distress syndrome,macrosomia and low-birth-weight infants were 52.38%,19.05%,21.43%,19.05%,19.05% and 21.43%,which were higher than 30.95%,2.38%,4.76%,2.38%,2.38% and 2.38% in the control group,and there was significant difference between the two groups(P<0.05).Conclusion In patients with gestational diabetes,Helicobacter pylori infection has a greater impact on blood glucose and lipid levels,and increases the rate of cesarean section,as well as pre-eclampsia,postpartum hemorrhage,neonatal respiratory distress syndrome,macrosomia,and low-birth-weight infants.Therefore,for patients with gestational diabetes,early detection of Helicobacter pylori should be carried out to clarify their infection,so as to implement early intervention and improve pregnancy outcomes.
作者
苏加碧
李姝静
谢飞
丁文
SU Jia-bi;LI Shu-jing;XIE Fei(Physical Examination Department,Sanming Maternal and Child Health Hospital,Sanming 365001,China)
出处
《中国现代药物应用》
2024年第22期67-69,共3页
Chinese Journal of Modern Drug Application
关键词
幽门螺杆菌
感染
妊娠期糖尿病
血糖
血脂
Helicobacter pylori
Infection
Gestational diabetes
Blood glucose
Blood lipid
作者简介
通讯作者:丁文。
