摘要
目的采用两样本孟德尔随机化分析探讨绿茶摄入量及消费频率与2型糖尿病之间的因果关系,旨在为两者之间的潜在关联提供更可靠的证据。方法使用GWAS数据库数据,采用逆方差加权法(IVW)作为主要分析方法,用MR-Egger回归法、加权中位数法作为补充。敏感性分析中,采用Cochran’s Q进行异质性检验,并通过MR-Egger回归法截距和MR-PRESSO方法评估多效性。结果IVW结果显示,绿茶摄入量与2型糖尿病存在负向因果关系(OR=0.996,95%CI:0.994~0.999,P=0.005);加权中位数法、MR-Egger回归法与IVW方向一致,分别为(OR=0.993,95%CI:0.988~0.997,P=0.007)和(OR=0.995,95%CI:0.992~0.998,P=0.001)。同样,绿茶消费频率也显示与2型糖尿病存在负向因果关系(OR=0.857,95%CI:0.781~0.940,P=0.001),加权中位数(OR=0.992,95%CI:0.668~1.470,P=0.972)、MR-Egger与(OR=0.875,95%CI:0.773~0.991,P=0.036)与IVW方向一致。敏感性分析中均P>0.05,提示选定的单核苷酸多态性均不存在水平多效性和异质性。反向孟德尔随机化分析结果显示,2型糖尿病与绿茶摄入量和消费频率之间均未存在显著关联(P>0.05),提示2型糖尿病和绿茶摄入量和消费频率之间不存在反向因果关联。结论较高的绿茶摄入和消费频率可能有效降低2型糖尿病的发生风险。
Objective To explore the causal relationship between green tea intake and consumption frequency and diabetes mellitus type 2 using the two-sample Mendelian randomization,aiming to provide more robust evidence for their potential association.Methods Using GWAS database data,inverse variance weighted(IVW)was used as the main analysis method,supplemented by MR-Egger regression method and weighted median method.In sensitivity analysis,Cochran’s Q was used to test for heterogeneity testing,and pleiotropy was assessed using the MR-Egger regression method intercept and MR-PRESSO method.Results The IVW showed a significant negative causal association between green tea intake and diabetes mellitus type 2(OR=0.996,95%CI:0.994-0.999,P=0.005).The weighted median method(OR=0.875,95%CI:0.773-0.991,P=0.036)and MR-Egger regression method were consistent with IVW direction,which were(OR=0.993,95%CI:0.988-0.997,P=0.007)and(OR=0.995,95%CI:0.992-0.998,P=0.001).Similarly,green tea consumption frequency also showed a negative association with diabetes mellitus type 2(OR=0.857,95%CI:0.781-0.940,P=0.001).The weighted median method and MR-Egger regression method(OR=0.992,95%CI:0.668-1.470,P=0.972)were consistent with IVW direction,respectively.Sensitivity analysis showed that all P>0.05 for all the selected single nucleotide polymorphisms did not have horizontal pleiotropy and heterogeneity.Reverse Mendelian randomization analysis showed no significant association between diabetes mellitus type 2 and green tea intake and consumption frequency(P>0.05),indicating that there was no reverse causal association between diabetes mellitus type 2 and green tea intake and consumption frequency.Conclusion Higher green tea intake and consumption frequency may be effective in reducing the risk of diabetes mellitus type 2.
作者
杨文菲
蒋新军
张翔
叶彩花
周启威
YANG Wenfei;JIANG Xinjun;ZHANG Xiang;YE Caihua;ZHOU Qiwei(International Nursing School,Hainan Medical University,Hainan Province,Haikou571199,China;Department of Nursing,the First Affiliated Hospital of Hainan Medical University,Hainan Province,Haikou571000,China)
出处
《中国医药导报》
CAS
2024年第27期15-21,共7页
China Medical Herald
基金
国家自然科学基金青年科学基金资助项目(82304262)。
关键词
绿茶摄入量
绿茶消费频率
2型糖尿病
孟德尔随机化
Green tea intake
Green tea consumption frequency
Diabetes mellitus type 2
Mendelian randomization
作者简介
杨文菲(1990.10-),男,海南医科大学国际护理学院2022级护理专业在读硕士研究生,研究方向:慢性病;通讯作者:蒋新军(1990.8-),女,博士,副研究员,研究方向:慢性病管理。
