摘要
近年来,我国卒中患病率逐年上升,幸存患者增加,迫切需要提高其生活质量和改善预后。随着生物信息学和基因组学技术的发展,很多研究显示缺血性脑卒中(IS)与遗传因素密切相关。本文基于炎症相关基因、血栓形成相关基因、基因多态性与血管疾病以及氧化应激相关基因等因素与IS发病风险的关系,从基因变异、遗传易感性、表观遗传学和相关研究方法等角度揭示缺血性脑卒中的发病机制和风险预测,为IS的病因诊断和个性化治疗提供依据,有助于有效改善幸存患者的预后和提高其生存质量。
In recent years,as the incidence rate of stroke in China has been increasing,the number of survivors has also been rising,highlighting an urgent need to improve their quality of life and outcome.Recent advances in bioinformat⁃ics and genomics have unraveled close links between ischemic stroke and genetic factors.This review aims to elucidate the relationship between the risk of ischemic stroke risk and inflammation-related genes,thrombosis-related genes,genetic polymorphisms in vascular diseases,and oxidative stress-related genes,and discuss the pathogenesis and risk prediction of ischemic stroke from the perspectives of genetic variation,genetic susceptibility,epigenetics,and related research methods.These insights may provide a reference for the etiological diagnosis and personalized treatment of ischemic stroke,so as to improve survivor’s outcome and quality of life.
作者
任帆舟
罗钰鼎(综述)
王建(审校)
REN Fanzhou;LUO Yuding;WANG Jian(North Sichuan Medical College,Nanchong 637000,China)
出处
《中风与神经疾病杂志》
CAS
2024年第11期1042-1046,共5页
Journal of Apoplexy and Nervous Diseases
基金
中央引导地方科技发展专项(2022ZYD0097)
四川省卫健委临床研究专项基金(23LCYJ034)
四川省医学会青年基金(Q21049)
四川省医学科技创新研究会科研课题(YCH-ZZ2023-010)。
作者简介
通信作者:王建,E-mail:wangjian0724@126.com。
