摘要
目的分析在功能性消化不良伴胃炎患者的治疗方案中应用奥美拉唑联合替普瑞酮的治疗价值。方法选择2021年3月至2023年3月于南安市梅山镇卫生院消化内科就诊的70例功能性消化不良伴胃炎患者为研究对象,按照分层随机法进行分组。两组均应用基础治疗,对照组(n=35)增加奥美拉唑,观察组(n=35)在对照组基础上增加替普瑞酮。针对两组患儿的临床症状积分、胃部排空情况、胃黏膜功能、炎症因子水平、不良反应进行比较。结果治疗后,观察组疼痛、腹胀、反酸恶心评分均较对照组低(均P<0.05)。治疗后,观察组胃半排空时间、胃排空时间、2 h留存率均较对照组低(均P<0.05)。治疗后,观察组胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)高于对照组,胃泌素水平低于对照组(均P<0.05)。治疗后,观察组白细胞介素4(IL-4)、白细胞介素10(IL-10)、C反应蛋白(CRP)等炎症因子水平较对照组优(P<0.05)。两组患儿不良反应发生率比较,结果差异无统计学意义(P>0.05)。结论在功能性消化不良伴胃炎患者的治疗方案中应用奥美拉唑联合替普瑞酮可提高消化功能,促进胃内容物排空,能明显改善疼痛、胃胀等功能性消化不良症状,修复胃黏膜功能和降低炎症因子水平,同时联合用药不良反应少,用药安全可靠。
Objective To analyze the therapeutic value of combining omeprazole with teprenone in the treatment plan for patients with functional dyspepsia and gastritis.Methods A total of 70 patients with functional dyspepsia and gastritis who were admitted to the Gastroenterology Department of Meishan Town Health Center in Nan’an City from March 2021 to March 2023 were selected as the research subjects and divided into groups according to stratified random sampling.Both groups received anti-HP basic treatment.The control group(n=35)increased omeprazole,and the observation group(n=35)increased teprenone on top of the control group’s treatment.The clinical symptom scores,gastric emptying,gastric mucosal function,inflammatory factor levels,and adverse reactions of the two groups were compared.Results After treatment,the pain,bloating,acid reflux nausea scores of the observation group were lower than those of the control group(all P<0.05).After treatment,gastric half-emptying time,gastric emptying time,and 2 h retention rate were lower in the observation group than in the control group(all P<0.05).After treatment,pepsinogenⅠ(PGⅠ)and pepsinogenⅡ(PGⅡ)of the observation group were higher than those of the control group,and gastrin levels were lower than those of the control group(all P<0.05).After treatment,the levels of inflammatory factors such as interleukin 4(IL-4),interleukin 10(IL-10),C-reactive protein(CRP)were better in the observation group than in the control group(P<0.05).Comparison of the incidence of adverse reactions between the two groups of children,the results were not statistically significant(P>0.05).Conclusions The combination of omeprazole and teprenone in the treatment plan for patients with functional dyspepsia and gastritis can improve digestive function,promote gastric content emptying,significantly improve symptoms such as pain and dyspepsia,repair gastric mucosal function,and reduce inflammatory factor levels.At the same time,the combined treatment has fewer adverse reactions and is safe and reliable.
作者
李小哲
LI Xiaozhe(Department of Gastroenterology,Meishan Town Health Center,Nan’an City,Nan’an 362321,China)
出处
《中国医药指南》
2024年第34期29-32,共4页
Guide of China Medicine
