摘要
Background There is a lack of further exploration of the epileptogenic network of specific types of epilepsy,such as unilateral hippocampal sclerosis(HS),and there is an urgent need to find exact evidence to confirm the consistency of its brain network changes.Methods We enrolled 22 mesial temporal lobe epilepsy with hippocampal sclerosis(mTLE-HS)patients to compare the differences in brain activity between 22 healthy controls(HCs)and them.Resting-state electroencephalography(EEG)was also measured.Then,we calculated the power spectral density and phase locking values in and between these electrodes.Results The results showed the increased theta power was related to the high severity of epilepsy in the temporal,parietal,and central regions in mTLE-HS patients,and there were positive correlations between theta power in the contralateral temporal region and seizure frequency.Theta power in the ipsilateral parietal lobe is positively correlated with the number of anti-seizure medications(ASMs),but not with the usage of third-generation ASMs.Meanwhile,the temporal lobe of mTLE-HS patients had more connectivity with parietal lobe and central region.
基金
National Key R&D Program of China(2022YFC2503801)
Cadre Health Care Project of the Sichuan Provincial Department of Health(2023–110)
National College Student Innovation and Entrepreneurship Training Program(C2024131786).
作者简介
Chenxi Qiu,contributed equally to the article;Chenxi Zhong,contributed equally to the article;Correspondence:Bo Yan,yanbo@wchscu.edu.cn;Correspondence:Xiaoting Hao,sherryhao@wchscu.cn。
