摘要
目的 探讨阿戈美拉汀治疗高血压合并抑郁的临床疗效。方法 共纳入2020年6月~2024年1月84例高血压合并抑郁患者,抛硬币法随机分为两组。患者均进行降压治疗,对照组41例采用舍曲林治疗,观察组43例采用阿戈美拉汀治疗。比较治疗前后匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、汉密尔顿抑郁量表17项(Hamilton depression scale-17,HAMD-17)以及血压变异系数,比较治疗4周、8周时治疗副反应量表(Treatment emergent symptom scale,TESS)。结果 治疗后两组患者PSQI指数、HAMD-17评分较治疗前均显著下降,但观察组治疗后PSQI指数低于对照组(P<0.05);治疗后两组患者血压变异系数均显著下降,但观察组治疗后血压变异系数低于对照组(P<0.05);观察组治疗4周、8周时TESS评分均低于对照组(P<0.05)。结论 阿戈美拉汀治疗高血压合并抑郁与舍曲林在改善抑郁情绪方面效果相当,但前者能够提升睡眠质量,稳定动脉血压,不良反应更轻。
Objective To explore the clinical efficacy of agomelatine in the treatment of hypertension combined with depression.Methods Eighty-four patients with hypertension and depression were included from January 2020-December 2023 were selected,and they were randomly divided into two groups using the coin toss method.All patients underwent antihypertensive treatment,with a control group of 41 cases treated with sertraline and an observation group of 43 cases treated with agomelatine.The Pittsburgh sleep quality index before and after treatment,(PSQI)、 The Hamilton Depression Scale 17,(HAMD-17) and coefficient of variation of blood pressure were compared.The Treatment Emergency Symptom Scale at 4 and 8 weeks of treatment,(TESS) were compared.Results PSQI index of two groups of patients after treatment The HAMD-17 score significantly decreased compared to before treatment,but the PSQI index in the observation group was lower than that in the control group after treatment(P<0.05).After treatment,the coefficient of variation of blood pressure in both groups of patients significantly decreased,but the coefficient of variation of blood pressure in the observation group was lower than that in the control group(P<0.05).At 4 and 8 weeks of treatment,the TESS score in the observation group was lower than that in the control group(P<0.05).Conclusion Agomelatine in the treatment of hypertension with depression is equivalent to sertraline in improving depressive mood,but the former can improve sleep quality,stabilize arterial blood pressure,and have milder adverse reactions.
作者
鲍永蓓
邹华
韩世文
万超
BAO Yongbei;ZOU Hua;HAN Shiwen(Department of Pharmacy,Xuancheng Central Hospital,Xuancheng 242000,China)
出处
《国际精神病学杂志》
2024年第5期1527-1529,共3页
Journal Of International Psychiatry
关键词
阿戈美拉汀
舍曲林
高血压合并抑郁
睡眠质量
动脉血压
Agomelatine
Sertraline
Hypertension combined with depression
Sleep quality
Arterial blood pressure
作者简介
第一作者/通讯作者:鲍永蓓(1990.09-),女,安徽宣城人,本科,主管药师,研究方向:临床药学,Email:13405589349@163.com。
