摘要
目的评估基于前列腺成像报告和数据系统2.1版本(prostate imaging-reporting and data system version 2.1,PI-RADS v2.1)及多参数磁共振成像(multiparametric magnetic resonance imaging,mp-MRI)衍生标志物用于移行带临床显著性前列腺癌(clinically significant prostate cancer,csPCa)检测的价值。材料与方法回顾性分析2020年1月至2024年2月在我院行mp-MRI及病理活检的移形带前列腺疾病患者的临床及影像学资料。由具有8年前列腺成像经验的主治医生基于PI-RADS v2.1对MRI图像进行评估,并勾画病变轮廓,从而获得包括三维直径、相对病变体积(病变体积除以前列腺体积)、球形度、平整度及表面体积比等MRI特征。使用logistic分析,确定PI-RADS评分及多参数MRI衍生标志物与移行带csPCa检测的关系。结果纳入的403例患者中PI-RADS 1(n=25)、2(n=119)、3(n=130)、4(n=43)和5(n=86)类病变的csPCa检出率分别为0.00%、0.00%、3.85%、32.56%和70.93%。PI-RADS 3类、4类、5类的csPCa检出率差异具有统计学意义(P<0.001)。移行带csPCa的预测因子包括血清前列腺特异性抗原(prostate-specific antigen,PSA)[OR=1.05(95%CI:1.00~1.10);P=0.047]、PI-RADS[OR=8.92(95%CI:2.94~27.13);P<0.001]、最大二维直径[OR=0.84(95%CI:0.71~0.98);P=0.046]及网格体积[OR=1.00(95%CI:1.00~1.00);P=0.041]。结论血清PSA、PI-RADS评分、病灶直径及网格体积等是移行带csPCa的独立预测因子。
Objective:To assess the value of prostate imaging-reporting and data system version 2.1(PI-RADS v2.1)and multi-parametric magnetic resonance imaging(mp-MRI)derived biomarkers in detecting clinically significant prostate cancer(csPCa)in transition zone.Materials and Methods:A retrospective analysis was conducted on clinical and imaging data from patients with transition zone prostate disease who underwent mp-MRI and pathological biopsy at our hospital from January 2020 to February 2024.MRI images were evaluated by a chief physician with 8 years of experience in prostate imaging,using PI-RADS v2.1 to assess the images and outline lesion contours.This provided MRI characteristics including 3D diameter,relative lesion volume(calculated by dividing the lesion volume by the prostate volume),sphericity,flatness,and surface volume ratio.Logistic analysis was used to determine the relationship between PI-RADS scores,multiparametric MRI-derived biomarkers,and the detection of csPCa in the transition zone.Results:The study included 403 patients.The detection rates of csPCa for PI-RADS categories 1(n=25),2(n=119),3(n=130),4(n=43),and 5(n=86)were 0.00%,0.00%,3.85%,32.56%,and 70.93%,respectively.The differences in csPCa detection rates among PI-RADS categories 3,4,and 5 were statistically significant(P<0.001).Predictive factors for csPCa in the transition zone included serum prostate-specific antigen(PSA)[OR=1.05(95%CI:1.00-1.10);P=0.047],PI-RADS score[OR=8.92(95%CI:2.94-27.13);P<0.001],maximum two-dimensional diameter[OR=0.84(95%CI:0.71-0.98);P=0.046],and grid volume[OR=1.00(95%CI:1.00-1.00);P=0.041].Conclusions:Serum PSA,PI-RADS score,lesion diameter,and grid volume are independent predictors of clinically significant prostate cancer in the transition zone.
作者
林燕顺
张丽
郑鹏翔
高永清
赵莹莹
徐伟
LIN Yanshun;ZHANG Li;ZHENG Pengxiang;GAO Yongqing;ZHAO Yingying;XU Wei(Department of Radiology,Fuqing City Hospital Affiliated to Fujian Medical University,Fuqing 350300,China;Department of Urology,Fuqing City Hospital Affiliated to Fujian Medical University,Fuqing 350300,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2024年第10期109-114,共6页
Chinese Journal of Magnetic Resonance Imaging
基金
福建省卫生健康科技计划项目(编号:2021QNA067)
福州市卫生健康系统科技计划项目(编号:2022-S-wq17)
福建医科大学启航基金项目(编号:2023QH1371)。
关键词
临床显著性前列腺癌
移行带
衍生标志物
磁共振成像
前列腺成像报告和数据系统
clinically significant prostate cancer
transitional zone
derived marker
magnetic resonance imaging
prostate imaging reporting and data system
作者简介
通信作者:徐伟,E-mail:1584016959@qq.com。
