摘要
肺癌是全球范围内最常见的一种癌症,也是导致癌症相关死亡的主要原因之一。其中非小细胞肺癌(NSCLC)占约85%。N6-甲基腺苷(m6A)是RNA的表观遗传修饰之一,异常的m6A修饰与多种疾病,尤其是肿瘤的进展和预后密切相关。非编码RNA(ncRNAs),如微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)等参与了肿瘤的发生、转移和其他相关恶性表型的过程。本文综述了m6A和ncRNAs之间的相互作用,阐明了它们之间错综复杂的相互作用,为NSCLC的临床诊断和治疗提供了新的思路。
Lung cancer is the most common cancer and one of the leading causes of cancer-related death worldwide,with non-small cell lung cancer(NSCLC)accounting for the majority,comprising approximately 85%of cases.The N6-methyladenosine(m6A)modification is an epigenetic alteration of RNA that plays a crucial role in the progression and prognosis of various diseases,particularly tumors.The involvement of non-coding RNAs(ncRNAs),such as microRNAs(miRNA),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs),has been implicated in the processes of tumorigenesis,metastasis,and other associated malignant phenotypes.This review provides a comprehensive overview of the interplay between m6A and ncRNAs,elucidating their intricate interactions that hold potential for novel insights into the clinical diagnosis and treatment of NSCLC.
作者
郑健豪
柯希贤
宋永祥
Zheng Jianhao;Ke Xixian;Song Yongxiang(Department of Thoracic Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi Guizhou 563000,China)
出处
《遵义医科大学学报》
2024年第11期1122-1133,共12页
Journal of Zunyi Medical University
基金
贵州省科技计划项目[NO:黔科合支撑(2021)一般082,黔科合基础-ZK(2022)一般644]。
作者简介
通信作者:宋永祥,男,教授,硕士生导师,研究方向:胸部肿瘤的基础与临床研究,E-mail:songtang2004@163.com。
