摘要
目的:分析不同剂量右美托咪定联合布托啡诺硬膜外麻醉在分娩镇痛中有效性及安全性。方法:选取2021年5月—2023年6月吉林省肿瘤医院麻醉科收治的120例足月分娩产妇为研究对象,随机分为观察组与对照组,各60例。对照组采用小剂量盐酸右美托咪定联合布托啡诺麻醉,观察组采用大剂量盐酸右美托咪定联合布托啡诺麻醉。对比两组镇痛镇静效果、炎性因子、应激水平、安全性。结果:镇痛后10 min、镇痛后30 min,两组视觉模拟评分法评分降低,且观察组低于对照组,两组Ramsay镇静量表评分升高,且观察组高于对照组(P<0.05);镇痛后,两组白细胞介素-6、肿瘤坏死因子-α、C反应蛋白、皮质醇、去甲肾上腺素水平降低,且观察组低于对照组(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论:在分娩镇痛中采用大剂量盐酸右美托咪定联合布托啡诺硬膜外麻醉的镇静镇痛效果更好,可有效改善炎性因子及应激指标水平,缓解疼痛且不影响安全性。
Objective:To analyze the effectiveness and safety of different doses of dexmedetomidine combined with butorphanol epidural anesthesia in labor analgesia.Methods:One hundred and twenty cases of full-term delivery admitted to the Department of Anesthesiology of Jilin Cancer Hospital from May 2021 to June 2023 were selected for the study,and were randomly divided into the observation group and the control group,sixty cases each.The control group was anesthetized with small-dose dexmedetomidine hydrochloride combined with butorphanol,and the observation group was anesthetized with high-dose dexmedetomidine hydrochloride combined with butorphanol.The analgesic and sedative effects,inflammatory factors,stress levels,and safety were compared between the two groups.Results:10 min after analgesia and 30 min after analgesia,the visual analog scale scores of the two groups decreased,and the observation group was lower than the control group,and the Ramsay sedation scale scores of the two groups increased,and the observation group was higher than the control group(P<0.05);after analgesia,the levels of interleukin-6,tumor necrosis factor-α,C-reactive protein,cortisol and norepinephrine decreased in the two groups,and the observation group was lower than the control group(P<0.05);the difference in the incidence rate of adverse reactions was not statistically significant when comparing the two groups(P>0.05).Conclusion:The use of high-dose dexmedetomidine hydrochloride combined with butorphanol epidural anesthesia in labor analgesia has a better sedative and analgesic effect,which can effectively improve the level of inflammatory factors and stress indicators,relieve pain without affecting safety.
作者
王怀武
王海玉
门璐
周金田
Wang Huaiwu;Wang Haiyu;Men Lu;Zhou Jintian(Department of Anesthesiology,Changchun Guowen Hospital1,Changchun 130022,Jilin Province,China;Department of Anesthesiology,Jilin Cancer Hospital2,Changchun 130012,Jilin Province,China)
出处
《中外医药研究》
2024年第29期27-29,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
作者简介
通信作者:周金田。
