摘要
目的观察芪榔方治疗气阴两虚型功能性便秘的临床疗效。方法纳入2023年1—9月收治的80例气阴两虚型功能性便秘患者为研究对象,随机分为试验组(芪榔方治疗)和对照组(枸橼酸莫沙必利片治疗),每组40例,疗程8周。治疗后随访8周,主要疗效指标为临床有效率,次要疗效指标为平均每周完全自主排便次数(complete spontaneous bowel movement,CSBM)、便秘主要症状总分、气阴两虚中医证候积分、中文版便秘患者生活质量量表(patient-assessment of constipation quality of life,PAC-QOL)评分、抑郁自评量表(self-rating depression scale,SDS)以及焦虑自评量表(self-rating anxiety scale,SAS)评分。结果试验组和对照组均无明显不良反应发生。治疗8周后,试验组的总有效率为92.5%,对照组为72.5%,差异有统计学意义(P<0.05)。治疗8周后,试验组的便秘主要症状总分较对照组降低2.6分(P<0.001);次要症状评分除心烦不眠外,其余均优于对照组(P<0.05)。随着治疗时间的延长,两组平均每周CSBM均增加,且试验组较对照组增加幅度更大(P<0.05);治疗8周后,试验组平均每周CSBM较对照组增加0.725次(P<0.05)。治疗8周后,试验组PAC-QOL评分优于对照组(P<0.001);SDS评分和SAS评分明显降低,且低于对照组(P<0.001)。结论芪榔方能够有效缓解气阴两虚型功能性便秘患者的便秘主要症状,增加平均每周CSBM次数,提高生活质量,改善不良情绪。
Objective To ascertain the clinical efficacy of Qilang formula in addressing functional constipation of the Qi and Yin deficiency type.Methods We enrolled 80 patients with this condition who were treated at the Department of Gastroenterology from Traditional Chinese Medicine Hospital,from January 2023 to September 2023.These patients were randomly divided into two groups:an experimental group and a control group,with 40 patients in each.The experimental group was treated with Qilang formula and the control group was treated with mosapride for 8 weeks,followed by an 8-week follow-up.The primary efficacy indicator was the clinical effective rate,and the secondary efficacy indicators included the average number of complete spontaneous bowel movements(CSBM)per week,total score of constipation main symptoms,traditional Chinese medicine(TCM)syndrome score of Qi and Yin deficiency,PAC-QOL score,SAS score,and SDS score.Results Both groups completed the study with 40 cases each,and no significant adverse reactions were observed.The experimental group exhibited a clinical effective rate of 92.5%,while the control group showed a rate of 72.5%(P<0.05)after treatment,indicating a statistically significant difference.The total score of constipation main symptoms in the experimental group decreased by 2.6 points compared to the control group(P<0.001)after treatment.After 8 weeks of treatment,except for insomnia and restlessness,the TCM secondary symptom scores in the experimental group were better than those in the control group(P<0.05).With the extension of the treatment time,the average CSBM per week in both groups increased,and the increase was greater in the experimental group than in the control group.After 8 weeks of treatment,the average CSBM per week in the experimental group increased by 0.725 times compared to the control group(P<0.05).After 8 weeks of treatment,the quality of life scores in the experimental group were better than those in the control group(P<0.001).The SDS and SAS scores in the experimental group significantly decreased after 8 weeks of treatment and were better than those in the control group(P<0.001).Conclusion The Qilang formula is effective in alleviating the primary symptoms of constipation in patients with functional constipation due to Qi and Yin deficiency,increasing the average number of CSBMs per week,improving the quality of life,and reducing negative emotions.
作者
李家诚
汪彦平
张克慧
郑逸远
李勇
LI Jiacheng;WANG Yanping;ZHANG Kehui;ZHENG Yiyuan;LI Yong(Department of Gastroenterology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai,200071,China)
出处
《中国中西医结合消化杂志》
CAS
2024年第11期971-978,共8页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
上海医学创新发展基金会“未来计划”(No:WL-YBXM-2022002K)
上海市2022年度“科技创新行动计划”生物医药科技支撑专项(No:22S21901100)。
关键词
芪榔方
功能性便秘
随机对照试验
气阴两虚
临床疗效
Qilang formula
functional constipation
randomized controlled trial
Qi and Yin deficiency
clinical efficacy
作者简介
通讯作者:李勇,E-mail:liyong@shutcm.edu.cn。
