摘要
目的探讨柴胡加龙骨牡蛎汤对痰热内扰型广泛性焦虑症(GAD)患者的效果。方法选取2022年3月—2024年1月乌鲁木齐市第四人民医院收治的92例痰热内扰型GAD患者为研究对象,按随机数字表法将其分为对照组和观察组,各46例。对照组采用阿普唑仑治疗,观察组在对照组基础上采用柴胡加龙骨牡蛎汤治疗。比较两组的临床疗效、中医证候积分、焦虑程度、神经递质水平及不良反应发生情况。结果观察组治疗总有效率为95.65%,高于对照组的82.61%,差异有统计学意义(P<0.05)。治疗后,观察组心悸、心烦、焦虑不安、失眠多梦积分均低于对照组,组间差异有统计学意义(P<0.05);观察组汉密尔顿焦虑量表、焦虑自评量表评分均低于对照组,组间差异有统计学意义(P<0.05);观察组多巴胺、5-羟色胺、去甲肾上腺素水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论柴胡加龙骨牡蛎汤可缓解痰热内扰型GAD患者的焦虑症状,能够调节神经递质水平,且无严重不良反应,有一定的应用价值。
Objective To explore the effect of Chaihujialonggumuli decoction on patients with phlegm-heat internal disturbance type of generalized anxiety disorder(GAD).Methods A total of 92 patients with phlegm-heat internal disturbance type of GAD admitted to the Fourth People's Hospital of Urumqi from March 2022 to January 2024 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 46 cases in each group.The control group was treated with alprazolam,and the observation group was treated with Chaihujialonggumuli decoction on the basis of the control group.The clinical efficacy,TCM syndrome score,anxiety degree,neurotransmitter level and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.65%,which was higher than 82.61%of the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of palpitation,upset,anxiety,insomnia and dreams in the observation group were lower than those in the control group,and the differences between the two groups were statistically significant(P<0.05);the Hamilton Anxiety Scale and Self-Rating Anxiety Scale scores of the observation group were lower than those of the control group,and the differences between the two groups were statistically significant(P<0.05);the levels of dopamine,5-hydroxytryptamine and norepinephrine in the observation group were lower than those in the control group,and the differences between the two groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Chaihujialonggumuli decoction can relieve the anxiety symptoms of patients with phlegm-heat internal disturbance type of GAD,regulate the level of neurotransmitters,and has no serious adverse reactions,so it has certain application value.
作者
孙靖
帕丽扎提·巴合提
SUN Jing;PALIZHATI Baheti(Department of Integrative Chinese and Western Medicine,The Fourth People's Hospital of Urumqi,Urumqi 830000,China)
出处
《反射疗法与康复医学》
2024年第12期1-4,共4页
Reflexology And Rehabilitation Medicine
关键词
广泛性焦虑症
痰热内扰型
柴胡加龙骨牡蛎汤
中医证候
Generalized anxiety disorder
Phlegm-heat internal disturbance type
Chaihujialonggumuli decoction
TCM syndrome
作者简介
孙靖(1986-),女,山东济宁人,本科,主治医师,研究方向:神志病诊疗。
