摘要
特应性皮炎(AD)是最常见的慢性炎症性皮肤病之一,与遗传、皮肤屏障缺陷、宿主免疫反应、变应原敏感性、环境影响和感染等多种因素有关。AD的特点是表皮屏障功能紊乱和过度活跃的免疫反应。目前认为,皮肤微生物组紊乱与AD病程之间存在联系。通常,细菌和病毒感染存在于AD患者的湿疹样病变中,并明显加重症状。皮肤微生物菌群和细菌生物膜会对皮肤屏障功能产生负面影响,导致AD的发作和恶化。以皮肤屏障为目标的局部治疗有助于更深入地开发新微生物组。
Atopic dermatitis(AD)is one of the most common chronic inflammatory skin diseases,which is related to various factors such as genetics,skin barrier defects,host immune response,allergen sensitivity,environmental influences,and infections.The characteristics of AD are dysfunction of the epidermal barrier and overactive immune response.At present,it is believed that there is a link between skin microbiome disorders and the course of AD.Typically,bacterial and viral infections exist in eczema-like lesions of AD patients and significantly worsen symptoms.The skin microbiota and bacterial biofilm can have a negative impact on the skin barrier function,leading to the onset and deterioration of AD.Local treatments targeting the skin barrier can help develop new microbiomes from deeper compartments.
作者
艾丽皮热·艾克白尔
帕丽达·阿不力孜
AILIPIRE Aikebaer;PALIDA Abulizi(Department of Dermatology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China)
出处
《医学综述》
CAS
2024年第23期2880-2884,2891,共6页
Medical Recapitulate
作者简介
通信作者:帕丽达·阿不力孜,Email:palidea@aliyun.com。
