摘要
目的:探讨血清血小板计数与淋巴细胞计数比值(PLR)、中性粒细胞计数与淋巴细胞计数比值(NLR)和白细胞介素33(IL-33)水平与心律失常型冠心病(Arrhythmogenic Coronary Heart Disease,ACHD)老年患者冠状动脉狭窄程度的临床相关性。方法:连续选取2022年1月-2022年12月在我院确诊为ACHD的患者88例,采用双抗体夹心酶联免疫吸附法(ELISA法)测定外周血IL33水平,流式细胞仪测定血清血小板、淋巴细胞、中性粒细胞个数,所有研究对象均接受为期6 m随访,随访结束后依据冠脉狭窄程度划分为观察组(Gensini积分>53分,n=29)和对照组(Gensini积分≤53分,n=59),比较两组血清PLR、NLR和IL-33水平差异,采用Person检验临床相关性,ROC结果分析PLR、NLR和IL-33联合诊断效能。结果:观察组患者PLR和NLR水平均高于对照组,IL-33水平低于对照组,差异具有统计学意义(P<0.05)。PLR和NLR与ACHD老年患者冠状狭窄程度分级均呈正相关性(P<0.05);IL-33呈负相关性(P<0.05)。ROC曲线分析PLR、NLR和IL-33联合诊断效能为。结论:ACHD患者血清PLR、NLR和IL-33水平均与冠状动脉狭窄程度密切相关。
Objective:To explore the clinical correlation between serum Platelet-to-Lymphocyte Ratio(PLR):Neutrophil-to-Lymphocyte Ratio(NLR),Interleukin-33(IL-33)levels and the degree of coronary stenosis in elderly patients with arrhythmogenic coronary heart disease(ACHD).Method:A total of 88 patients who were diagnosed with ACHD in our hospital from January 2022 to December 2022 were continuously selected.Peripheral blood IL-33 levels were measured by a sandwich enzyme-linked immunosorbent assay(ELISA):and the serum platelet,lymphocyte,and neutrophil counts were determined by flow cytometry.All research subjects were observed for six months.After the follow-up period,they were divided into an observation group(Gensini score>53,n=29)and a control group(Gensini score≤53,n=59)based on the degree of coronary stenosis.The differences in serum PLR,NLR and IL-33 levels between the two groups were compared.The clinical correlation was assessed via Pearson's test,and the combined diagnostic efficacy of PLR,NLR,and IL-33 was analyzed using ROC results.Result:In the observation group,both the PLR and NLR levels were higher than in the control group,while the level of IL-33 was lower than that in the control group.The differences had statistical significance(P<0.05).PLR and NLR were positively correlated with the degree of coronary artery stenosis in elderly ACHD patients(P<0.05);IL-33 was negatively correlated(P<0.05).ROC curve analysis indicated the combined diagnostic efficiency of PLR,NLR,and IL-33.Conclusion:The levels of serum PLR,NLR,and IL-33 in ACHD patients are closely related to the degree of coronary artery stenosis.
作者
吉晓菲
董丽
Ji Xiao-fei;Dong Li(Department of Clinical Laboratory,Zheng Zhou Central Hospital Affiliated to Zheng Zhou University,Zhengzhou 450001,China)
作者简介
吉晓菲,女,主管技师,主要从事临床生物化学检验;Email:jixiaofeivip@163.com;通讯作者:董丽,女,副主任技师,主要从事临床检验诊断学及临床微生物学研究,Email:1648978377@qq.com
