摘要
目的分析对于急性ST段抬高型心梗死(ST-elevation myocardial infarction,ASTEMI)并行经皮冠状动脉介入术(percutaneous coronary intervention,PCI)治疗的患者,在治疗过程中合用替格瑞洛片的效果及其对心功能的影响。方法非随机选取山东省菏泽市牡丹人民医院于2021年1月—2023年7月收治的ASTEMI患者92例纳入研究,按照用药方式不同分为对照组和观察组,各46例。对照组采用阿司匹林片+硫酸氢氯吡格雷片治疗,观察组采用阿司匹林片+替格瑞洛片治疗。对比两组患者的疗效、心功能指标、不良事件发生情况。结果观察组的治疗总有效率为95.65%(44/46),高于对照组的82.61%(38/46),差异有统计学意义(χ^(2)=4.039,P<0.05)。观察组的左心室射血分数、峰值射血率指标均高于对照组,左心室舒张末期内径、左心室收缩末期容积指数均低于对照组,差异有统计学意义(P均<0.05)。观察组的不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论在PCI手术过程中使用替格瑞洛片治疗急性ST段抬高型心肌梗死患者具备较好的效果,其能够有效改善患者的心功能,且安全性更高,具有一定的临床意义。
Objective To analyze the effect of ticagrelor tablets combined with percutaneous coronary intervention(PCI)on patients with acute ST-elevation myocardial infarction(ASTEMI)and its effect on cardiac function.Methods A total of ninety-two patients with ASTEMI admitted to Heze Mudan People's Hospital of Shandong Province from January 2021 to July 2023 were non-randomly selected and divided into control group and observation group according to different medication methods,with forty-six cases in each group.The control group was treated with aspirin tablets+clopidogrel hydrogen sulfate tablets,and the observation group was treated with aspirin tablets+ticagrelor tablets.The efficacy,cardiac function indexes and adverse events were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.65%(44/46),which was higher than 82.61%(38/46)in the control group,and the difference was statistically significant(χ^(2)=4.039,P<0.05).The left ventricular ejection fraction and peak ejection rate of the observation group were higher than those of the control group,and the left ventricular end-diastolic diameter and left ventricular end-systolic volume index were lower than those of the control group,the differences were statistically significant(all P<0.05).The incidence of adverse events in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The use of ticagrelor tablets in the treatment of patients with acute ST-segment elevation myocardial infarction during PCI surgery has a good effect,which can effectively improve the cardiac function of patients,and has higher safety and certain clinical significance.
作者
李俊梅
LI Junmei(Department of Internal Medicine,Heze Mudan People's Hospital of Shandong Province,Heze 274000,Shandong,China)
出处
《系统医学》
2024年第18期104-107,共4页
Systems Medicine
作者简介
李俊梅(1986-),女,本科,副主任医师,研究方向为心电图诊断。
